ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Wearables – A Next Big Thing for ME/CFS and Fibromyalgia?

Acupressure Mats for Better Sleep in Fibromyalgia and Chronic Fatigue Syndrome

Natural Treatments For Mild Cognitive Impairment – Might these also help the “fog” of FM and CFS?

A Chronic Fatigue Syndrome (ME/CFS) / Fibromyalgia Lifestyle: What Works for Me

Getting Well: A Chronic Fatigue Syndrome and Fibromyalgia Mind Game

Joint Aches May Have Met Their Match in Curcumin

Chronic Pain and the Opioid Epidemic: Wicked Issues Have No Simple Solutions

Choosing Where to Place Your Focus When You Are Diagnosed with Chronic Lyme Disease

VIDEO: Things People With Chronic Pain Want You to Learn

Chronic Fatigue Syndrome Studies Link Autonomic Nervous System Problems to Brain

 
Print Page
Email Article

CoQ10 supports reversal of statin-caused mitochondrial dysfunction, energy drain

  [ 19 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 11, 2012


Article:
Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance
- Source: Journal of Applied Physiology, May 31, 2012

By A Muraki, K Miyashita, et al.

[Note: Atorvastatin, aka Lipitor, is a lipophilic statin, meaning it dissolves in & is attracted to lipids (fats). Prevastatin, aka Pravachol, is a hydrophilic statin, meaning it dissolves in water, and so is believed to have less muscle penetration than lipophilic statins.]

Abstract:
Background: Statins are cholesterol-lowering drugs widely used in the prevention of cardiovascular diseases; however, they are associated with various types of myopathies.

Statins inhibit HMG-CoA reductase and thus decrease biosynthesis of low-density lipoprotein cholesterol and may also reduce ubiquinones, essential coenzymes of a mitochondrial electron transport chain, which contain isoprenoid residues, synthesized through an HMG-CoA reductase-dependent pathway.

Therefore, we hypothesized that statin treatment might influence physical performance:

• Through muscular mitochondrial dysfunction

• Due to ubiquinone deficiency.

Methods and Results:

The effect of two statins, atorvastatin and pravastatin, on ubiquinone content, mitochondrial function and physical performance was examined by using statin-treated mice.

Changes in energy metabolism in association with statin-treatment were studied by using cultured myocytes.

We found that atorvastatin-treated mice developed:

• Muscular mitochondrial dysfunction due to ubiquinone deficiency,

• And a decrease in exercise endurance,

• Without affecting muscle mass and strength.

Meanwhile, pravastatin at 10 times higher dose [than] atorvastatin had no such effects.

In cultured myocytes, atorvastatin-related decrease in mitochondrial activity led to:

• A decrease in oxygen utilization

• And an increase in lactate production.

Conversely, coenzyme Q10 treatment in atorvastatin-treated mice:

• Reversed atorvastatin-related mitochondrial dysfunction

• And a decrease in oxygen utilization,

• And thus improved exercise endurance.

Conclusion:

Atorvastatin decreased exercise endurance in mice through mitochondrial dysfunction due to ubiquinone deficiency.

Ubiquinone supplementation with coenzyme Q10 could reverse atorvastatin-related mitochondrial dysfunction and decrease in exercise tolerance.

Source: Journal of Applied Physiology, May 31, 2012. DOI:10.1152/japplphysiol.01362 by Muraki A, Miyashita K, Mitsuishi M, Tamaki M, Tanaka K, Itoh H. Keio University School of Medicine, Minato, Tokyo, Japan. [Email: miyakaza2sc.itc.keio.ac.jp]





Post a Comment

Featured Products From the ProHealth Store
Hydroxocobalamin Extreme™ Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map