ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Twenty-Six Years of Hell: An ME/CFS/FM Recovery Story

What Makes You Forget?

Motivation: It's Not What You Think

The Opioid Painkiller Clampdown – Will it Lead to Better Drugs?

Top 10 Gifts to People Living with Pain

An Alternative to Goals and Resolutions: Intentions and Extreme Permissiveness

Could Chronic Fatigue Syndrome (ME/CFS) Be a Chronic Form of Sepsis?

Chronic Fatigue Syndrome (ME/CFS) Researcher and Patients Shine During NIH Call

Unrest Flies High, Dr. Oz Talks ME/CFS and Ms Magazine Delivers

Urgency: Ron Davis and His (Non-NIH Funded) ME/CFS Collaborative Research Center

 
Print Page
Email Article

B-cell alterations in ME/CFS ‘may suggest subtle tendency to autoimmunity’

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 4, 2012


Article:
Altered functional B-cell subset populations in patients with chronic fatigue syndrome compared to Healthy Controls
- Source: Clinical & Experimental Immunology, Nov 2012

By A.S. Bradley, B. Ford, A.S. Bansal

[Note: This article, abstracted below, is not yet available in formatted full text. The research took place at an NHS center serving ME/CFS patients in southwest London and Surrey.]

Abstract:
Chronic Fatigue Syndrome (CFS) is a heterogeneous disorder of unknown aetiology characterised by disabling fatigue, headaches, sleep disturbance and several other symptoms.

The onset of CFS may follow a viral infection or period of stress. Patients with CFS do not have hypogammaglobulinaemia, predisposition to recurrent bacterial infections or symptoms of autoimmunity.

To date, defects in B-cell numbers or function have not been shown in the literature. [In autoimmune disorders such as RA, immune B cells mistakenly attack self.] However, treatment with anti-B-cell therapy using Rituximab has recently shown benefit to CFS patients.

We therefore postulated that patients with CFS had a subtle humoral [found in the body fluids] immune dysfunction, and performed extended B-cell immunophenotyping.

We undertook a detailed characterization of the proportions of the different B-cell subsets in 33 patients with CFS fulfilling the Canadian and Fukuda criteria for CFS and compared these with 24 age and gender matched healthy controls (HC).

CFS patients had:

• Greater numbers of naïve B-cells as a % lymphocytes - 6.3 % versus 3.9 % in HC (P=0.034),

• Greater numbers of naïve B-cells as a % of B-cells - 65 % versus 47 % in controls (P=0.003),

• Greater numbers of transitional B-cells - 1.8 % versus 0.8 % in controls (P=0.025)

• And reduced numbers of plasmablasts - 0.5 % versus 0.9 % in controls (P=0.013).

While the cause of these changes is unclear, we speculate whether they may suggest a subtle tendency to autoimmunity.

Source: Clinical & Experimental Immunology, abstract online Nov 2012, full text article not yet formatted. DOI: 10.1111/cei.12043, by Bradley AS, Ford B, Bansal AS. Department of Immunology, St. Helier University Hospital NHS Trust, Carshalton, Surrey, UK. [Email: Amolak.Bansal@esth.nhs.uk]





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength MitoQ®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map