Activate Now
 
ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Exercise Intolerance in POTS, ME/CFS and Fibromyalgia Explained?

#ISpeakForPain Blitz

5 Ways That I Reduce Stress During Tough Times

Move More: How I Actually Started Exercising with a Chronic Condition

GUIDELINES FOR PAIN WARRIORS

8 Things to Consider for Depression

VIDEO: Living with Chronic Pain

ACTION ALERT: Improve US chronic pain care

Genes Highlight Inflammation and Mast Cells in Fibromyalgia

Moving Forward When a Treatment Proves Unsuccessful

 
Print Page
Email Article

Cerebral vascular control is associated with skeletal muscle pH in chronic fatigue syndrome patients both at rest and during dynamic stimulation

  [ Not Yet Rated ]   [ Discuss This Article ]
By Jiabao He et al. • www.ProHealth.com • February 11, 2013


Cerebral vascular control is associated with skeletal muscle pH in chronic fatigue syndrome patients both at rest and during dynamic stimulation

– Source: NeuroImage: Clinical, Volume 2, 2013

By Jiabao He, Kieren G. Hollingsworth, Julia L. Newton, and Andrew M. Blamire

Abstract

Cerebral blood flow (CBF) is maintained despite changing systemic blood pressure through cerebral vascular control, with such tight regulation believed to be under local tissue control. Chronic fatigue syndrome (CFS) associates with a wide range of symptoms, including orthostatic intolerance, skeletal muscle pH abnormalities and cognitive impairment. CFS patients are known to have reduced CBF and orthostatic intolerance associates with abnormal vascular regulation, while skeletal muscle pH abnormalities associate with autonomic dysfunction. These findings point to autonomic dysfunction as the central feature of CFS, and cerebral vascular control being influenced by factors outside of the brain, a macroscopic force affecting the stability of regional regulation. We therefore explored whether there was a physiological link between cerebral vascular control and skeletal muscle pH management in CFS.

Seventeen consecutive CFS patients fulfilling the Fukuda criteria were recruited from our local CFS clinical service. To probe the static scenario, CBF and skeletal muscle pH were measured at rest using MRI and 31P magnetic resonance spectroscopy (31P-MRS).

To examine dynamic control, brain functional MRI was performed concurrently with Valsalva manoeuvre (VM), a standard autonomic function challenge, while 31P-MRS was performed during plantar flexion exercise.

Significant inverse correlation was seen between CBF and skeletal muscle pH at rest (r = ? 0.67, p < 0.01). Prolonged cerebral vascular constriction during the sympathetic phase of VM was associated with higher pH in skeletal muscle after plantar flexion exercise (r = 0.69, p < 0.008).

In conclusion, cerebral vascular control is closely related to skeletal muscle pH both at rest and after dynamic stimulation in CFS.

Highlights

  • Cerebral vascular control in CFS is affected by factors external to the brain.
  • Valsalva manoeuvre performed during fMRI probes cerebral vascular control.
  • Cerebral blood flow is associated with skeletal muscle pH at rest in CFS.
  • Cerebral vascular control relates to skeletal pH recovery after stimulation in CFS.
  • Our results point towards a peripheral or systemic cause for CFS.

Source: NeuroImage: Clinical,Volume 2, 2013, Pages 168–173. By Jiabao He, Institute of Cellular Medicine & Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom; Kieren G. Hollingsworth, Institute of Cellular Medicine & Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom; Julia L. Newton, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; and Andrew M. Blamire Institute of Cellular Medicine & Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.

Note: You may read the full text of this article free HERE.

Editor's Comment: In this study the researchers propose that CFS is driven by a primary peripheral abnormality - higher pH (alkalinity) in skeletal muscle leads to the CNS abnormalities characteristic of CFS.





Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ Mitochondria Ignite™ with NT Factor® MitoQ®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Magnesium: An Essential Supplement for ME/CFS Magnesium: An Essential Supplement for ME/CFS
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map