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Relationship between autonomic cardiovascular control, case definition, clinical symptoms, and functional disability in adolescent chronic fatigue syndrome: An exploratory study

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By Vegard Bruun Wyller and Ingrid B Helland • www.ProHealth.com • February 12, 2013


 Note: The head-up tilt table table (HUT) is used to diagnose postural orthostatic tachycardia syndrome (POTS). POTS is common among adolescents with ME/CFS, particularly young women.

Relationship between autonomic cardiovascular control, case definition, clinical symptoms, and functional disability in adolescent chronic fatigue syndrome: An exploratory study

– Source: BioPsychoSocial Medicine, 2013, 7:5 doi:10.1186/1751-0759-7-5 

By Vegard Bruun Wyller and Ingrid B Helland

Abstract (provisional)

Chronic Fatigue Syndrome (CFS) is characterized by severe impairment and multiple symptoms. Autonomic dysregulation has been demonstrated in several studies. We aimed at exploring the relationship between indices of autonomic cardiovascular control, the case definition from Centers for Disease Control and Prevention (CDC criteria), important clinical symptoms, and disability in adolescent chronic fatigue syndrome.

38 CFS patients aged 12--18 years were recruited according to a wide case definition (ie. not requiring accompanying symptoms) and subjected to head-up tilt test (HUT) and a questionnaire. The relationships between variables were explored with multiple linear regression analyses. In the final models, disability was positively associated with symptoms of cognitive impairments (p<0.001), hypersensitivity (p<0.001), fatigue (p=0.003) and age (p=0.007). Symptoms of cognitive impairments were associated with age (p=0.002), heart rate (HR) at baseline (p=0.01), and HR response during HUT (p=0.02). Hypersensitivity was associated with HR response during HUT (p=0.001), high-frequency variability of heart rate (HF-RRI) at baseline (p=0.05), and adherence to the CDC criteria (p=0.005). Fatigue was associated with gender (p=0.007) and adherence to the CDC criteria (p=0.04).

In conclusion:

a) The disability of CFS patients is not only related to fatigue but to other symptoms as well;

b) Altered cardiovascular autonomic control is associated with certain symptoms;

c) The CDC criteria are poorly associated with disability, symptoms, and indices of altered autonomic nervous activity.

Source: BioPsychoSocial Medicine, 2013, 7:5 [doi:10.1186/1751-0759-7-5]. Vegard Bruun Wyller, Department of Paediatrics, Oslo University Hospital and University of Oslo; and Ingrid B Helland, Department of Paediatrics, Oslo University Hospital, Oslo, Norway.  

Note: The complete article is available HERE as a provisional PDF. The fully formatted PDF and HTML versions are in production.





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