ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ten Tips to Simplify, Lower the Cost, and Optimize CFS and fibromyalgia Treatment

Keep Learning – Even From Bed!

Why You Should Make Your Pleasure a Top Priority

Factors Associated with Increased Risk for Clinical Insomnia in Patients with Chronic Neck Pain.

Researchers Identify Characteristic Chemical Signature for Chronic Fatigue Syndrome

SURVEY: Weight Management & Chronic Illness

When Retreat Means Advance: A Recovered Chronic Fatigue Syndrome/Fibromyalgia Patient Looks Back

The NIH’s Big Change: Is it Coming For Chronic Fatigue Syndrome (ME/CFS)?

VIDEO: September is Pain Awareness Month

Metabolic features of chronic fatigue syndrome

 
Print Page
Email Article

UK Charity Launches Major Study Into CFS/ME and Pain

  [ 7 votes ]   [ 2 Comments ]
www.ProHealth.com • March 2, 2013


~Source: The CFS Research Foundation

The CFS Research Foundation, based in Hertfordshire, England, has agreed to fund an ambitious, cutting edge study into why so many Chronic Fatigue Syndrome/ME sufferers experience heightened pain. The three-year study will be conducted by a team of UK scientists and clinicians at Bart’s and the London Medical School, Imperial College and Imanova, a centre of excellence for imaging sciences. 

Entitled “The neurophysiology of pain in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)”, the study will seek to discover the physiological and chemical abnormalities underlying pain in CFS/ME patients. A large majority of people with CFS/ME suffer from a number of painful symptoms including muscle and joint pain, headaches, sore throat and lymph node pain. Many endure chronic widespread pain which can become unbearable. An additional problem for these sufferers is that normal pain killers do little to ease their pain. 

Scientists and doctors know very little about why pain is such a problem but there is some evidence to suggest that the way the brain handles pain signals in CFS/ME patients is different from that in healthy people. There are two potential reasons: spinal sensitisation, in which non-painful sensations are felt as painful because nerves that are not specialised in detecting pain tell the spinal cord that what is being felt is hurting us, (called allodynia) while mildly painful sensations are felt as unbearable because the brain’s natural defences don’t fire and central augmentation in which the brain’s pain matrix becomes overly sensitive, reacting faster than normal to the possibility of pain which it then interprets as being more painful and unpleasant. Together these are referred to as Central Sensitisation. This condition is not specific to CFS/ME but the particular biological and biomedical mechanisms which cause it in CFS/ME sufferers is unknown. 

The research team will attack the problem on four fronts. Firstly, they will measure pain thresholds to a number of potentially painful stimuli (e.g. pressure and heat) and assess whether there is spinal cord sensitivity to pain (spinal sensitisation). Secondly, they will use cutting edge fMRI (functional Magnetic Resonance Imaging) to scan the brains of CFS/ME patients, to examine the pain matrix (pain pathways), and see how they differ from healthy controls. Thirdly, they will use two medications that block two of the brain’s pain chemical transmitters (dopamine and the opioids) in combination with fMRI to see how they are involved in the pain pathways and the response to pain. Finally, the team will see whether the differences in pain levels, central sensitisation and activity of the pain matrix are related to differences in a particular gene in CFS/ME patients. 

The research will lead to a better understanding of how the brain is involved in pain symptoms in CFS/ME patients, how certain brain chemicals and the gene involved in their metabolism, are involved and thus provide a way forward to consider more effective treatments. 

The CFS Research Foundation’s Honorary Director, Anne Faulkner said: “The Foundation maintains its belief that it is essential that the basis of CFS/ME must continue to be at the top of its agenda. We must understand the causes of the disease before we can find a cure. While our long term research continues, we decided it was time to widen our research by trying to obtain a deeper understanding of how one particular organ might be involved in causing a particularly distressing symptom endured by many people with CFS/ME – namely pain. To find therapies to relieve pain could change lives.” 

You can find out more about the CFS Research Foundation and its work by visiting its website 

 



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength MitoQ® Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Barking up the wrong tree - again
Posted by: IanH
Mar 2, 2013
This idea that pain in ME/CFS is a sensitivity issue is far from the whole story and it ignores the important studies by Prof. Alan Light which tells us that the origin of much of the pain is immunological via a low grade inflammatory process. Some of the pain originates in muscle and other fibrous tissue which when over worked creates (yes creates) pain due to the sustained release of pro-inflammatory and pain generating and amplifying cytokines.

The sensitivity theory suggests that the sensations are normal but interpreted as pain and there is no muscle or fibrous tissue problem. This is insufficient to explain the data.

To me this study and the money allocated to it is mis-guided. However it will no doubt uncover some useful information.
Reply Reply

Look at the personnel
Posted by: 43
Mar 5, 2013
This sounds good on paper, but the CFSRF has now engaged Esther Crawley to their Research Committee, which should sound warning bells for anyone with authentic ME who doesn't think their disease can be treated using mind manipulation such as LP.

http://cfsrf.org.uk/index.php?option=com_content&view=article&id=51:research-committee&catid=35:who-is-involved&Itemid=59
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map