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Bacteriotherapy Achieves 70% Success Rate in CFS Patients

  [ 28 votes ]   [ 3 Comments ]
By Thomas Borody et al • • March 3, 2013

Editor’s Comment: This study builds on previous research demonstrating abnormal bacterial gut flora in ME/CFS patients. In addition to causing numerous gastrointestinal symptoms, prior studies have found that abnormal gut flora in ME/CFS patients is linked to cognitive dysfunction (Maes and De Meirleir). This is the first study to demonstrate a complete remission of symptoms in a significant percentage of ME/CFS patients after the normalization of gut flora.

The GI microbiome and its role in Chronic Fatigue Syndrome:  A summary of bacteriotherapy

~Source: Journal of the Australasian College of Nutritional and Environmental Medicine, December 2012

By Thomas Borody et al


Introduction: Chronic Fatigue Syndrome (CFS) has a complex and multifactorial etiology making treatment and definitive diagnosis, currently made through exclusion, difficult. Current therapies, such as cognitive behavior therapy and graded exercises, are inadequate and targeted to address symptoms, rather than the underlying disease pathology. Increasing evidence implicates the microbiota of the gut in a number of conditions previously thought distinct from the gastrointestinal system. Previous work with bacteriotherapy in CFS has suggested a link between the condition and the composition and health of the gut microbiota. Here, we review and further examine a larger cohort of CFS patients who had undergone bacteriotherapy for their CFS.

Method: A total of 60 patients from the Centre for Digestive Diseases presented with CFS. Of these, 52 patients had concurrent IBS and 4 patients additionally had constipation. All underwent initial transcolonoscopic infusion of 13 non-pathogenic enteric bacteria. 52/60 patients undertook an additional rectal infusion a day later and 3/60 undertook an additional 2 rectal infusions.

Results: 35/60 patients who underwent initial bacteriotherapy responded to treatment. 10/15 patients who failed this course were offered a secondary transcolonoscopic infusion followed by a rectal infusion or an oral course of cultured bacteria.

Of these 7/10 responded, giving a total of 42/60 (70%) patients who responded to treatment. Contact was achieved with 12 patients after 15-20 year follow-up. Complete resolution of symptoms was maintained in seven of the twelve patients and 5/12 did not experience recurrence for approximately 1.5-3 years post bacteriotherapy.

Conclusion: Bacteriotherapy achieves initial success rate of 70% in CFS and a 58% sustained response. Given that manipulation of the colonic microbiota improved CFS symptoms, bacteriotherapy for CFS warrants further investigation and may provide further insight into a possible etiology of CFS.

Source: Journal of the Australasian College of Nutritional and Environmental Medicine, Vol. 31, No. 3, Dec 2012: 3-8. Borody, Thomas, Director, Centre for Digestive Diseases, Five Dock NSW 2046, Australia; Nowak, Anna, Research Assistant, Centre for Digestive Diseases, Australia; Finlayson, Sarah, Research Assistant, Centre for Digestive Diseases, Five Dock NSW 2046, Australia.

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Article Comments Post a Comment

Where in the U.S.A. or U.K.?
Posted by: valspal18
Mar 6, 2013
Is there anywhere that i can try this therapy?
Reply Reply

and the names of the bacteria were ????
Posted by: Sandy10m
Mar 27, 2013
I can't believe they left out the species of bacteria that were found to be so helpful. For those of us who cannot get the therapy, at least we can build a cocktail of the helpful bacteria from the study and take them orally. So, what in the heck are the names of the bacteria???
Reply Reply

Faecal Microbiota Transplant (FMA)
Posted by: anna_1234
Apr 1, 2013

Here is a blog all about Faecal Microbiota Transplants with a list of clinics who offer it:
Reply Reply

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