ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

The END ME/CFS Project

The CFS/ME Brain Is Inflamed

SURVEY: Cognitive Impairment

Disability Claims and Social Media

Ask the Doctor: What Are Your Favorite Treatments for ME/CFS?

High-Throughput Sequencing of Plasma MicroRNA in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Epigenetics & immune dysfunction in ME/CFS

“End ME/CFS” Mega Chronic Fatigue Syndrome Project Begins

Use of single-nucleotide polymorphisms (SNPs) to distinguish gene expression subtypes of chronic fat...

Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalom...

 
Print Page
Email Article

Altered Functional B Cell Subset Populations in Patients With Chronic Fatigue Syndrome Compared to Healthy Controls

  [ 3 votes ]   [ 1 Comment ]
By A. S. Bradley et al. • www.ProHealth.com • March 21, 2013


Editor's Note: Naive B cells are immune system cells that have not been exposed to an antigen, that is, they have not "learned" to identify an invader. Plasmablasts perform a similar function. Transitional B cells are cells that have not yet been transformed into different classes of immune cells. A large proportion of immature B cells leads to a decrease in a person's ability to combat previously encountered pathogens (humoral immunity). A shift toward increased numbers of immature B cells is found in autoimmune disease, such as lupus.

~Source: Clinical & Experimental Immunology, April 2013

By A. S. Bradley et al.

Summary

Chronic fatigue syndrome (CFS) is a heterogeneous disorder of unknown aetiology characterized by disabling fatigue, headaches, sleep disturbance and several other symptoms. The onset of CFS may follow a viral infection or period of stress. Patients with CFS do not have hypogammaglobulinaemia, predisposition to recurrent bacterial infections or symptoms of autoimmunity. To date, defects in B cell numbers or function have not been shown in the literature. However, treatment with anti-B cell therapy using Rituximab has recently shown benefit to CFS patients. We therefore postulated that patients with CFS had a subtle humoral immune dysfunction, and performed extended B cell immunophenotyping. We undertook a detailed characterization of the proportions of the different B cell subsets in 33 patients with CFS fulfilling the Canadian and Fukada criteria for CFS and compared these with 24 age- and gender-matched healthy controls (HC). CFS patients had greater numbers of naive B cells as a percentage of lymphocytes: 6.3 versus 3.9% in HC (P?=?0.034), greater numbers of naive B cells as a percentage of B cells: 65 versus 47% in controls (P?=?0.003), greater numbers of transitional B cells: 1.8 versus 0.8% in controls (P?=?0.025) and reduced numbers of plasmablasts: 0.5 versus 0.9% in controls (P?=?0.013). While the cause of these changes is unclear, we speculate whether they may suggest a subtle tendency to autoimmunity.

Source: Clinical & Experimental Immunology, Volume 172, Issue 1, pages 73–80, April 2013 A. S. Bradley, B. Ford, A. S. Bansal.




Please Discuss This Article:   Post a Comment 

Not only autoimmunity
Posted by: IanH
Mar 21, 2013
This is the same state that exists in AIDS so besides autoimmunity it suggests a viral induced immuno-suppression.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing