ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Wearables – A Next Big Thing for ME/CFS and Fibromyalgia?

Acupressure Mats for Better Sleep in Fibromyalgia and Chronic Fatigue Syndrome

Natural Treatments For Mild Cognitive Impairment – Might these also help the “fog” of FM and CFS?

A Chronic Fatigue Syndrome (ME/CFS) / Fibromyalgia Lifestyle: What Works for Me

Getting Well: A Chronic Fatigue Syndrome and Fibromyalgia Mind Game

Joint Aches May Have Met Their Match in Curcumin

Chronic Pain and the Opioid Epidemic: Wicked Issues Have No Simple Solutions

Choosing Where to Place Your Focus When You Are Diagnosed with Chronic Lyme Disease

VIDEO: Things People With Chronic Pain Want You to Learn

Chronic Fatigue Syndrome Studies Link Autonomic Nervous System Problems to Brain

 
Print Page
Email Article

Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine

  [ Not Yet Rated ]   [ Discuss This Article ]
By K. Tokizane et al. • www.ProHealth.com • April 11, 2013


Editor's Note: VGF is increased after injury and under conditions of chronic pain and inflammation. Because VGF is found abundantly in the limbic system, it plays a role in regulating metabolism, energy homeostasis, and appetite. The term "cryptogenic" means the cause is unknown. 

~Source: Mol Cell Endocrinol. Mar 26, 2013. 

By K. Tokizane et al.

Abstract

Prolonged exposure to stress elicits profound effects on homeostasis that may lead to cryptogenic disorders such as chronic fatigue syndrome.

To investigate the pathophysiology associated with the syndrome, we used a rat continuous stress (CS) model where the pituitary represents one of the most affected organs. Here we found that mRNA for VGF (non-acronymic), a member of the granin family, was induced specifically in the intermediate lobe (IL).

This was matched by a concomitant increase at the peptide/protein level assessed by C-terminal antibody. Furthermore, the upregulation of VGF was confirmed by immunohistochemistry in a subset of melanotrophs.

VGF expression was altered in the IL of rats receiving the dopamine D2 receptor agonist bromocriptine or the antagonist sulpiride. In vitro, dopamine dose-dependently decreased the mRNA levels in cultured melanotrophs.

These findings suggest that VGF expression under CS is negatively regulated by dopaminergic neurons projecting from the hypothalamus.

Source: Mol Cell Endocrinol. 2013 Mar 26. pii: S0303-7207(13)00108-1. doi: 10.1016/j.mce.2013.03.012. [Epub ahead of print]. Tokizane K, Konishi H, Yasui M, Ogawa T, Sasaki K, Minamino N, Kiyama H., Department of Functional Anatomy and Neuroscience, Nagoya University, Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Hydroxocobalamin Extreme™ MitoQ®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Live Without Anxiety or Stress Live Without Anxiety or Stress
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map