ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

Researchers shed new light on cause of Chronic Fatigue Syndrome

Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

Brain abnormalities in ME/CFS

The role of Epstein-Barr virus infection in the development of autoimmune thyroid diseases

Heroes Amidst the Daily Grind of Chronic Illness

Looking After Yourself Isn’t Selfish

Adapting Successfully to Long Term Illness – May Start with Dumping the Denial

Australian Study Pinpoints Possible Gene Issues in Chronic Fatigue Syndrome

Safely Burn Away Body Fat

 
Print Page
Email Article

Pathomechanisms of Autoantibody Production against the Nervous System

  [ 2 votes ]   [ Discuss This Article ]
By K. Arimura • www.ProHealth.com • April 14, 2013


Editor's Comment: This study is the most recent addition to the body of evidence that infections may be precipitating factors in the later development of chronic inflammation and subsequent autoimmunity in the nervous system. In a previous study performed at Queen Mary, University of London, researchers found a similar link between Epstein-Barr virus and multiple sclerosis, another neuro-degenerative autoimmune disease.

~Source: Brain Nerve. April, 2013. [Article in Japanese]

By K. Arimura

Abstract

In immune-mediated neurological disorders, the production of autoantibodies against the nervous system occurs mainly because of impaired immune tolerance. In myasthenia gravis (MG), the thymus shows pathologic alterations, particularly in anti-AChR antibody-positive patients. Further, resection of the thymus induces a clinical recovery.

The MG thymus contains all the elements, including AChR antigens, AChR-specific T cells, and antigen-secreting B cells, that are required to initiate and sustain autoantibody production. Central tolerance, established by the repertoire selection of immature T lymphocytes in the thymus, is impaired in MG patients who are positive for anti-AChR antibodies.

Recent evidence suggests that chronic inflammation elicited by viral infection is important for the production of AChR antibodies. Antibodies against ganglioside are crucial for the diagnosis of Guillain-Barre syndrome (GBS). Molecular mimicry between the lipooligosaccharides of Camplylobacter jejuni and gangliosides of the peripheral nerve causes the production of antibodies. However, less than 1 in 1000 patients infected with C. jejuni develop GBS. This fact suggests that some host factors might influence the production of antibodies. A recent hypothesis suggests that transient impairment of peripheral tolerance due to infection may play a crucial role in GBS pathogenesis.

In summary, autoantibody production might correlate with the impairment of immune tolerance as well as with innate immunity.

Source: Brain Nerve. 2013 Apr;65(4):323-32. Arimura K. Okatsu Neurology and Rehabilitation Hospital.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Safely Burn Away Body Fat Safely Burn Away Body Fat
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing