ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

The MTHFR Mutation: Important for CFS-ME? Important for everything?

Happiness, Gratitude and Appreciation

New clinical research program to combat chronic pain and chronic fatigue syndrome

It’s Still a Wonderful Life

Survey Data on Name Change for ME/CFS Analyzed for Publication

Lack of Knowledgeable Healthcare Access for Patients with Neuro-endocrine-immune Diseases

Assessment of activity limitations and participation restrictions with persons with chronic fatigue ...

Help the National ME/FM Action Network win $5000!

Now Is the Time for a National PR Campaign for ME/CFS!

Shake That *^#&! ing Stigma – The “Shake the CFS Stigma Challenge” Begins

 
Print Page
Email Article

Patients With Allergies Prone to Atypical Herpesvirus Infections

  [ Not Yet Rated ]   [ Discuss This Article ]
www.ProHealth.com • April 27, 2013


Editor's Comment: This interesting study examines the link between allergies and herpesvirus reactivation.The author of the article proposes that individuals with allergies (atopic individuals) may be prone to more severe and atypical herpes-related illnesses, due to a TH2 shift in their immune systems. Interestingly, the reactivation of latent herpesviruses can actually provoke this shift by increasing the expression of immune-suppressing cytokines, such as IL-10 and IL-6. The author recommends treatment with antivirals for atopic patients who present with atypical symptoms of herpesvirus reactivation. The reactivation of latent herpesvirus due to a TH2 shift has long been proposed as one of the pathological mechanisms of CFS/ME. This study provides further support for the role of antivirals as a treatment for a subset of CFS/ME patients, particularly those with a history of allergies.

Herpes viruses and the microbiome

By David H. Dreyfus

Abstract

The focus of this article will be to examine the role of common herpesviruses as a component of the microbiome of atopic patients and to review clinical observations suggesting that atopic patients might be predisposed to more severe and atypical herpes-related illness because their immune response is biased toward a TH2 cytokine profile. Human populations are infected with 8 herpesviruses, including herpes simplex virus HSV1 and HSV2 (also termed HHV1 and HHV2), varicella zoster virus (VZV or HHV3), EBV (HHV4), cytomegalovirus (HHV5), HHV6, HHV7, and Kaposi sarcoma–associated herpesvirus (termed KSV or HHV8). Herpesviruses are highly adapted to lifelong infection of their human hosts and thus can be considered a component of the human “microbiome” in addition to their role in illness triggered by primary infection. HSV1 and HSV2 infection and reactivation can present with more severe cutaneous symptoms termed eczema herpeticum in the atopic population, similar to the more severe eczema vaccinatum, and drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is associated with reactivation of HSV6 and possibly other herpesviruses in both atopic and nonatopic patients. In this review evidence is reviewed that primary infection with herpesviruses may have an atypical presentation in the atopic patient and conversely that childhood infection might alter the atopic phenotype. Reactivation of latent herpesviruses can directly alter host cytokine profiles through viral expression of cytokine-like proteins, such as IL-10 (EBV) or IL-6 (cytomegalovirus and HHV8), viral encoded and secreted siRNA and microRNAs, and modulation of expression of host transcription pathways, such as nuclear factor ?B. Physicians caring for allergic and atopic populations should be aware of common and uncommon presentations of herpes-related disease in atopic patients to provide accurate diagnosis and avoid unnecessary laboratory testing or incorrect diagnosis of other conditions, such as drug allergy or autoimmune disease. Antiviral therapy and vaccines should be administered promptly when indicated clinically.

Source: The Journal of Allergy and Clinical Immunology, 22 April 2013 (10.1016/j.jaci.2013.02.039). David H. Dreyfus. Department of Pediatrics, Clinical Faculty, Yale School of Medicine, New Haven and the Center for Allergy, Asthma, and Immunology, Waterbury, Conn




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Live Longer: Groundbreaking Research on Omega-3s Live Longer: Groundbreaking Research on Omega-3s
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing