ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Orthostatic Intolerance, Part 1: Diagnosing OI

Yes, It Really Is Possible to Restore Mitochondrial Function!

Is Searching for THE Answer Making You Worse?

The Cure for Giving Up (When it Feels Like Chronic Pain Is Forever)

Orthostatic Intolerance, Part 2: Treating OI

Metabolomics Study Points Finger at Energy Production in Fibromyalgia

Gather Your Tribe

Horror to Hope: Grief to Action

Cellular Energy Production Takes Big Hit in Chronic Fatigue Syndrome (ME/CFS) Study

Cellular bioenergetics is impaired in patients with chronic fatigue syndrome

 
Print Page
Email Article

Case definitions and diagnostic criteria for myalgic encephalomyelitis and chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions

  [ 2 votes ]   [ 3 Comments ]
By G. Morris G et al. • www.ProHealth.com • June 4, 2013


By G. Morris G et al.

Abstract

The symptom spectrum of Myalgic Encephalomyelitis (ME) was first detailed in 1959 and later operationalised into a diagnostic protocol (Melvin Ramsey). In 1988 the Holmes case definition coined the term chronic fatigue syndrome (CFS). Fukuda's Centers for Disease Control and Prevention criteria are very heterogeneous and comprise patients with milder symptoms than the Holmes case definition.

The CDC Empirical Criteria for CFS lack sensitivity and/or specificity. Other CFS definitions, e.g. the Oxford criteria, delineate people with idiopathic fatigue. Some authors make the clinical CFS diagnosis when slightly increased self-rated fatigue scores are present. In 2011, Carruthers' International Consensus Criteria attempted to restore the focus on selecting people who suffer from ME.

Cognitive bias in criteria construction, patient selection, data collection and interpretation has led to the current state of epistemological chaos with ME, CFS, CFS/ME and ME/CFS, and CF being used interchangeably. Moreover, none of the above mentioned classifications meet statistically based criteria for validation. Diagnostic criteria should be based on statistical methods rather than consensus declarations. Ongoing discussions about which case definition to employ miss the point that the criteria did not pass appropriate external validation.

In 2012, Maes et al. performed pattern recognition methods and concluded that CFS patients (according to Fukuda's criteria) should be divided into those with CFS or ME, on the basis that people with ME display a worsening of their illness following increases in physical or cognitive activity.

Both ME and CFS are complex disorders that share neuro-immune disturbances, which are more severe in ME than in CFS. This paper expands on that strategy and details a range of objective tests, which confirm that a person with ME or CFS has a neuro-immune disease.

By means of pattern recognition methods future research should refine the Maes' case definitions for ME and CFS by including well-scaled symptoms, staging characteristics and neuro-immune biomarkers, including immune-inflammatory assays, bioenergetic markers and brain imaging.

Source: Neuro Endocrinol Lett. 2013 May 22;34(3):185-199. [Epub ahead of print]. Morris G, Maes M. Mumbles Head, Pembrey llanelli, UK. dr.michaelmaes@hotmail.com.





Post a Comment

Featured Products From the ProHealth Store
MitoQ® B-12 Extreme™ Ultra ATP+, Double Strength


Article Comments Post a Comment

?
Posted by: IanH
Jun 4, 2013
Who decided that ME is different from CFS???
Do we now have two diseases???
Reply Reply

 
Diagnostic criteria
Posted by: IanH
Jun 4, 2013
"Diagnostic criteria should be based on statistical methods rather than consensus declarations"

No they shouldn't. They should be based on biomarkers.

 

 
biomarkers
Posted by: IanH
Jun 4, 2013
When we have biomarkers or at least accept some of those we already have then we will be able to sort people on their severity against those biomarkers.. I am surprised that Michael Maes is suggesting this dichotomy, it is premature. We need more research into biomarkers AND more funding to clarify them.

 

 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map