ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|

Trending News

A Commercially Available Probiotic Reduces Chronic Fatigue Syndrome’s Inflammation—Should we offer t...

SURVEY RESULTS: What Name Would YOU Choose for CFS?

Simmaron’s Spinal Fluid Study Finds Dramatic Differences in Chronic Fatigue Syndrome

Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients

The Countess of Mar, Medical Politics, and ME/CFS

What were your first symptoms of ME/CFS?

ProHealth's 2014 Advocate of the Year – Ryan Prior

Life for a Young Person with M.E.

Cultivating Self-Compassion

Autoimmune Organization Makes Urgent Call For Fatigue Research

 
Print Page
Email Article

Clonidine Treatment in Adolescent Chronic Fatigue Syndrome

  [ 3 votes ]   [ Discuss This Article ]
By Dag Sulheim, MD at al. • www.ProHealth.com • February 19, 2014


Editor’s Comment: Sympathetic upregulation is common in patients with ME/CFS, and contributes to insomnia, migraines, nightmares, and feeling “tired and wired.” Clonidine inhibits sympathetic activity by reducing circulating epinephrine (adrenaline). Normally clonidine is used to treat high blood pressure, but off-label uses include sleep disorders, restless legs syndrome, anxiety disorders, and PTSD. While this study did not find clonidine effective for adolescents with ME/CFS, Dr. Jay Goldstein found that in adults it eliminated nightmares, reduced central pain, and, in  some patients, helped all symptoms. However, given the prevalence of orthostatic intolerance in adolescents with ME/CFS, it is not surprising that clonidine should have resulted in a reduction of physical activity (Stewart, 1999).Questions have also been raised concerning the ethics of testing drugs with potentially harmful side effects on ill children. (The age range in this study was 12-18 years.)

Disease Mechanisms and Clonidine Treatment in Adolescent Chronic Fatigue Syndrome: A Combined Cross-sectional and Randomized Clinical Trial

By Dag Sulheim, MD at al.

Abstract

Importance: Chronic fatigue syndrome (CFS) is a disabling condition with unknown disease mechanisms and few treatment options.

Objective: To explore the pathophysiology of CFS and assess clonidine hydrochloride pharmacotherapy in adolescents with CFS by using a hypothesis that patients with CFS have enhanced sympathetic activity and that sympatho-inhibition by clonidine would improve symptoms and function.

Design, Setting, and Participants: Participants were enrolled from a single referral center recruiting nationwide in Norway. A referred sample of 176 adolescents with CFS was assessed for eligibility; 120 were included (34 males and 86 females; mean age, 15.4 years). A volunteer sample of 68 healthy adolescents serving as controls was included (22 males and 46 females; mean age, 15.1 years). The CFS patients and healthy controls were assessed cross-sectionally at baseline.

Thereafter, patients with CFS were randomized 1:1 to treatment with low-dose clonidine or placebo for 9 weeks and monitored for 30 weeks; double-blinding was provided. Data were collected from March 2010 until October 2012 as part of the Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial.

Interventions: Clonidine hydrochloride capsules (25 µg or 50 µg twice daily for body weight <35 kg or >35 kg, respectively) vs placebo capsules for 9 weeks.

Main Outcomes and Measures Number of steps per day.

Results: At baseline, patients with CFS had a lower number of steps per day (P?
There were no significant differences regarding blood microbiology evaluation. During intervention, the clonidine group had a lower number of steps per day (mean difference, ?637 steps; P?=?.07), lower plasma norepinephrine level (mean difference, ?42 pg/mL; P?=?.01), and lower serum C-reactive protein concentration (mean ratio, 0.69; P?=?.02) compared with the CFS placebo group.

Conclusions and Relevance: Adolescent CFS is associated with enhanced sympathetic nervous activity, low-grade systemic inflammation, attenuated hypothalamus-pituitary-adrenal axis function, cognitive impairment, and large activity reduction, but not with common microorganisms. Low-dose clonidine attenuates sympathetic outflow and systemic inflammation in CFS but has a concomitant negative effect on physical activity; thus, sympathetic and inflammatory enhancement may be compensatory mechanisms. Low-dose clonidine is not clinically useful in CFS.

Source: Dag Sulheim, MD; Even Fagermoen, MD; Anette Winger, RN; Anders Mikal Andersen, BSc; Kristin Godang, BSc; Fredrik Müller, MD, PhD; Peter C. Rowe, MD, PhD; J. Philip Saul, MD; Eva Skovlund, PhD; Merete Glenne Øie, PhD; Vegard Bruun Wyller, MD, PhD. JAMA Pediatr. Published online February 03, 2014. doi:10.1001/jamapediatrics.2013.4647



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria

Natural Remedies

Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Eating Fat is Good… Maybe… Could Be… Sometimes Eating Fat is Good… Maybe… Could Be… Sometimes
Strontium - The Missing Mineral for Strong Bones
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing