ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

3 Things that Give Me Back More Energy Than They Take

Can you do Anil a favor? He needs our help!

Back to the Future—the Tragedy of Unrelieved Pain and Suffering

Give Dr. Ron Davis The Greatest Birthday Present

The Joy of Reading

VIDEO: Mindfulness and Chronic Pain

10 Things to Try When You're Feeling Lonely

Even “Minor” Infections Can Cause Chronic Fatigue Syndrome (ME/CFS)

Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue...

The Evolution of a Chronic Fatigue Syndrome (ME/CFS) Researcher? CBT Proponent Calls for More Herpes...

 
Print Page
Email Article

Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with CFS/ME

  [ 22 votes ]   [ 1 Comment ]
By Sharni Lee Hardcastle et al. • www.ProHealth.com • March 11, 2014


Note: The link to this article appears to be temporarily broken.

By Sharni Lee Hardcastle et al.

Abstract

Objective: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a disabling illness, characterized by persistent, debilitating fatigue and a multitude of symptoms. Immunological alterations are prominent in CFS/ME cases, however little is known about the relationship between CFS/ME severity and the extent of immunological dysfunction. The purpose of this study was to assess innate and adaptive immune cell phenotypes and function of two groups of CFS/ME patients, bedridden (severe) and mobile (moderate).

Methods: CFS/ME participants were defined using the Centres for Disease Prevention and Control (1994 CDC) Criteria for CFS/ME.

Participants were grouped into healthy controls (n=22, age=40.14 ± 2.38), moderate/mobile (n=23; age=42.52 ± 2.63) and severe/bedridden (n=18; age=39.56 ± 1.51) CFS/ME patients. Flow cytometric protocols were used to examine neutrophil, monocyte, dendritic cells (DCs), iNKT, Treg, B, gamma delta and CD8+ T cell phenotypes, NK cytotoxic activity and receptors.

Results: The present data found that CFS/ME patients demonstrated significant decreases in NK cytotoxic activity, transitional and regulatory B cells, gamma delta 1T cells, KIR2DL1/DS1, CD94+ and KIR2DL2/L3.

Significant increases in CD56-CD16+NKs, CD56dimCD16- and CD56brightCD16-/dim NKs, DCs, iNKT phenotypes, memory and naive B cells were also shown in CFS/ME participants. Severe CFS/ME patients demonstrated increased CD14-CD16+ DCs, memory and naïve B cells, total iNKT, iNKT cell and NK phenotypes compared to moderate CFS/ME patients.

Conclusion: This study is the first to determine alterations in NK, iNKT, B, DC and gamma delta T cell phenotypes in both moderate and severe CFS/ME patients. Immunological alterations are present in innate and adaptive immune cells and sometimes, immune deregulation appears worse in CFS/ME patients with more severe symptoms. It may be appropriate for CFS/ME patient severity subgroups to be distinguished in both clinical and research settings to extricate further immunological pathologies that may not have been previously reported.

Source: Sharni Lee Hardcastle, EkuaWeba Brenu, Samantha Johnston, Thao Nguyen, Teilah Huth, Manprit Kaur, Sandra Ramos1, Ali Salajegheh, Don Staines and Sonya Marshall-Gradisnik. Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with CFS/ME. Citation: Hardcastle SL, Brenu E, Johnston S, Nguyen T, Huth T, et al. (2014). Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). J Clin Cell Immunol 5: 190. doi:10.4172/2155-9899.1000190

Copyright: © 2014 Hardcastle SL, et al.




Post a Comment

Featured Products From the ProHealth Store
B-12 Extreme™ MitoQ® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Links not working
Posted by: IanH
Mar 11, 2014
The links to this articles give a 404 error
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map