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Study shows why exercise magnifies exhaustion for chronic fatigue syndrome patients

  [ 41 votes ]   [ 6 Comments ] • March 17, 2015

Study shows why exercise magnifies exhaustion for chronic fatigue syndrome patients
Press Release: University of Florida, March 12, 2015. The mechanism that causes high-performance athletes to “feel the burn” turns out to be the culprit in what makes people with chronic fatigue syndrome feel exhausted by the most common daily activities, new University of Florida Health research shows.

Published in the February issue of the journal Pain, the study shows that the neural pathways that transmit feelings of fatigue to the brain might be to blame. In those with chronic fatigue syndrome, the pathways do their job too well.

The findings also provide evidence for the first time that peripheral tissues such as muscles contribute to feelings of fatigue. Determining the origins of fatigue could help researchers develop therapies or identify targets for those therapies.

Researchers focused on the role of muscle metabolites, including lactic acid and adenosine triphosphate, or ATP, in the disease. The study has demonstrated for the first time that these substances, released when a person exercises his or her muscles, seem to activate these neural pathways. Also, UF Health researchers have shown that these pathways seem to be much more sensitive in patients with chronic fatigue syndrome than in patients without the disease, something that hasn’t been studied before.

Chronic fatigue syndrome, which the Institute of Medicine recently renamed systemic exertion intolerance disease, or SEID, is characterized by extreme chronic fatigue. Because its chief symptom -- fatigue -- is often associated with many other diseases, it can be difficult to diagnose SEID for the more than 1 million people who actually have the disease, according to the Centers for Disease Control and Prevention. The disease has no root medical cause, and researchers don’t know what triggers it. But they are studying aspects of the disease to figure out ways to treat it.

“What we have shown now, that has never been shown before in humans, is that muscle metabolites can induce fatigue in healthy people as well as patients who already have fatigue,” said Dr. Roland Staud, a professor of rheumatology and clinical immunology in the UF College of Medicine and the paper’s lead author.

During exercise, muscles produce metabolites, which are sensed by metaboreceptors that transmit information via fatigue pathways to the brain, according to the researchers. But in patients with SEID, these fatigue pathways have become highly sensitive to metabolites and can trigger excessive feelings of fatigue.

“For most of us, at the end of strenuous exertion we feel exhausted and need to stop — but we will recover rapidly,” Staud said. “However, these individuals tire much more rapidly and sometimes just after moving across a room, they are fully exhausted. This takes a toll on their lives.”

Staud and co-author Michael E. Robinson, a professor in the department of clinical and health psychology in the UF College of Public Health and Health Professions, recruited a group of 39 patients with SEID and 29 participants without the disease. The researchers asked the participants to don a blood pressure cuff just above their elbows on their dominant side, pick up a spring-loaded device and squeeze it to 100 percent of their maximum capacity, which was measured by a dial.

With research assistants encouraging them, the study participants then squeezed the device so that the dial showed they were gripping at 50 percent of their maximum capacity for as long as they could.

At the end of the hand-grip exercise, the blood pressure cuff on the participant’s arm was inflated, almost instantly trapping the metabolites generated by the exercise within the forearm muscles. This allowed the metabolites to collect in the forearm tissue without being cleared by the circulatory system. There, the metabolites continued to activate fatigue pathways, sending messages of fatigue to the brain and allowing researchers to measure how much fatigue and pain may occur because of the trapped metabolites.

With the blood pressure cuff still inflated, the participants rated fatigue and then pain in their forearms every 30 seconds. Both patients with SEID and patients without the disease reported increasing fatigue, but patients with the disease recorded much higher levels of fatigue and pain.

“We found that the fatigued individuals reported more fatigue than the non-fatigued individuals during the exercise, and also found that they had more pain compared to the non-fatigued individuals,” Staud said.

On the Fatigue Visual Analog Scale used to measure participants’ fatigue, patients with SEID rated their fatigue at approximately 5.5 on a scale of 0 to 10 after the hand-grip exercise while wearing the inflated blood pressure cuff, whereas participants without the disease rated their fatigue at approximately 1.5.

After 30 minutes, the participants repeated the exercise, but with the opposite arm and without the cinching blood pressure cuff so the metabolites could be cleared from the arm. Both sets of participants experienced fatigue, but the feeling of fatigue in those with the disease was much lower than when the metabolites were trapped with the blood pressure cuff.

“This suggests that hypersensitive fatigue pathways play an important role for the often pronounced exercise-related fatigue of patients with the disease,” Staud said.

Next, Staud plans to explore treatment interventions and to conduct brain-imaging studies of patients with SEID.

“The take-home message here is, like many of the pain studies we have conducted, there are both peripheral and central nervous system factors at play in these complex syndromes,” said Robinson, who is also the director of the UF Center for Pain Research and Behavioral Health. “Our study seems to highlight the important role of these peripheral tissues.”

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Article Comments Post a Comment

chronic fatigue .i call it (M,CEF )
Posted by:
Mar 18, 2015
i like the way the studys are going in chronic fatigue ive been saying for8 years i think it has something to do with the brain and neuropathways and lactic acid because feelings chronically tired all the time i have skitzophrenia anddrs think its the depression or illness ive been trying tell them for years its chronic fatigue then had a diaganosis it is debilatating maybe the chemicals that are released for sleep are being over produced or the brain is lacking something that makes you tired or a combination of things but i do like the way the research is going as been saying these kind of things for years and hope u find what the cause is and how to treat it thankyou .
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conclusion of study is confusing
Posted by: sterling222
Mar 18, 2015
I have had cfids and nmh/ncs for 15 yrs, up to that point was successful professional and competitive athlete. Had positive tilt table test. My normal functioning is currently down to about 20 percent. What is confusing about this study's conclusions is that when I am swimming in the pool (an activity that I learned after becoming ill) I can immediately do much more physical activity. I believe this is due to the vasoconstriction from the cold water, the fact that I am prone vs upright, the support I get from the water in general as well as a number of other benefits I wont go into here. After swimming i am able to do more than I would normally do and I feel much better. Quite frankly, I feel at this point swimming and weight lifting are keeping me out of a wheelchair or being totally bedridden.
Since becoming ill i have had 2 types of fatigue: 1 is a type where there is what i would call an "inappropriate fatigue" or an inappropriate lactic acid situation. My legs feel like i have run a marathon, but i havent. sometimes with the right activity (ie weight lifting) i can push through and warm up out of it . it is much to my benefit if i can. other times I cannot, and am forced to rest.
the other type of fatigue is a pronounced wilting like feeling where there is no option to work out of it, if i dont rest i am going to fall down. It is not related to anxiety or depression.
in either of these two types of fatigue, i highly suspect that the direct cause is that my heart does not have enough blood to pump at that moment. with proper pacing in the pool i can avoid this fatigue due to the benefits I already mentioned. The question then remains what is the root cause of my heart not getting enough blood?
could it be neural in origin? maybe. but then I dont know where this study's hypothesis would fit in. Perhaps some chronic fatigue patients have more of an autonomic ns problem than others?
Reply Reply

Posted by: Purrl
Mar 18, 2015
Thank you so much for your report of swimming benefits. I have long since wondered if swimming would be a good exercise for me, but to leave the house and return means extra fatigue. I've wanted to try a small water-jet type pool and see if it would be good to install as an addition to my house, but I don't have the income for that. Your report gave me hope. I'm sure now to pursue trial runs as my fatigue allows.


Finally, a way to prove it
Posted by: kesselmills
Mar 21, 2015
I am so grateful after all these years (got CFS/Me at 34, am 67 now), that a respected place has and is proving clearly how this illness actually works. It gives me hope that at some time during the time I have left to live, that there will be some major steps made for treating this life-robbing illness.
Reply Reply

Posted by: mimibb
Mar 22, 2015
What kind of dr. best addresses these kinds of health issues?
Reply Reply

Posted by: SoofK
Mar 28, 2015
In mý ME it's caused by a lack of them, induced by a stealth virus, causing kind of an ongoing drug underdose so instead of hyper, supersocial etc. you feel exhausted and...meh.

But perhaps that's just ME.
Reply Reply

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