Beyond any doubt, definitely. Do you get migraines also? I get long periods of extreme congestion, fatigue to the point of falling asleep in mid day, with severe depression. After a week or so of this, I get severe migraine cluster headaches for 3 to 5 days. I am then forced to take Imitrex and codiene. The migraine lifts after one to three days on the meds, and when it lifts the sinus clears, and the worst of the depression. My best , most trusted doctors tell me that this can not be related , but it happens the same way consistently , for decades. Sinus and migraine are two little understood conditions, with myriad variations and complications. Depression and neurological complaints are among them. Everyone is different. Here is what has worked for me to the best extent: Nasonex over other Rx spays, netti pot irrigations, and the best natural spray I have found in 50 years, Sinus Buster hot pepper nasal spray. There is a good essential oil inhalation combo, thyme, clove, cinnamon, in a Vicks steam inhaler. That and the pepper blast out congestion. Good luck.