I am thyroidless and take 6 grains daily. I take 4 grains early in the morning, along with my Cortisol and Iodoral Iodine. I take my remaining 2 grains, anytime between noon and 5pm, whenever I remember it. I take my Cortisol 4 times a day, again when I remember it. Avoid eating anything for an hour after taking thyroid hormones, and take no Calcium or Iron within a couple hours.