{"product_id":"prohealth-l-ergothioneine-25-mg-30-capsules-3-pack-ph646c","title":"L-Ergothioneine - 25 mg, 30 capsules - 3 pack","description":"\u003cdiv class=\"product-benefits-copy\"\u003e\n\u003ch2\u003eErgothioneine is a powerful amino acid that helps fight the signs of aging and supports numerous aspects of health.\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eSupports longevity by aiding in telomere length maintenence \u003csup\u003e1 \u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eCombats oxidative stress in the brain to support cognition \u003csup\u003e2\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eProtects the heart and is associated with reduced cardiovascular mortality \u003csup\u003e3\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0206\/3076\/5668\/files\/PH646_-_COA_Brighton__LOT_26052_2025-11-11_2.pdf?v=1763395761\" rel=\"noopener noreferrer\" style=\"color: #0000ff;\" target=\"_blank\"\u003eView Certificate of Analysis \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch-Supported Benefits:\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eSupports Longevity. \u003c\/strong\u003eResearch shows that ergothioneine supports longevity by protecting against accelerated telomere shortening. (1) Longer telomeres are a powerful predictor of increased lifespan and healthspan. (4)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaintains Cellular Health.\u003c\/strong\u003e Ergothioneine has been shown to reduce levels of oxidative stress. High levels of oxidative stress may contribute to DNA damage, a decline in ATP (cellular energy) production and elevated inflammatory markers. (5)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePromotes Heart Health. \u003c\/strong\u003eBy reducing oxidative stress, ergothioneine exhibits powerful cardioprotective properties. Oxidative stress is associated with accelerated aging of heart cells, studies show ergothioneine reduces cardiac-related mortality risk. (6)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnhances Brain Health. \u003c\/strong\u003eLow levels of ergothioneine are correlated with neurodegeneration and cognitive impairment. (7) Animal studies have found that administration of ergothioneine improves markers of memory and mood. (8)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImproves Performance. \u003c\/strong\u003eResearch suggests ergothioneine may improve markers associated with fitness and muscle health. One study found that administration ergothioneine to mice increased time to exhaustion during aerobic activity and enhanced protein synthesis post-exercise. (9)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e1. Samuel P, Tsapekos M, de Pedro N, Liu AG, Casey Lippmeier J, Chen S. Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions. J Diet Suppl. 2022;19(2):212-225. doi:10.1080\/19390211.2020.1854919 \u003cbr\u003e\u003cbr\u003e2. Wijesinghe P, Whitmore CA, Campbell M, et al. Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer's disease. Front Neurosci. 2023;17:1107436. Published 2023 Mar 14. doi:10.3389\/fnins.2023.1107436 \u003cbr\u003e\u003cbr\u003e3. Dare A, Elrashedy AA, Channa ML, Nadar A. Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats. Cardiovasc Hematol Agents Med Chem. 2022;20(2):133-147. doi:10.2174\/1871525719666210809122541 \u003cbr\u003e\u003cbr\u003e4. Heidinger BJ, Blount JD, Boner W, Griffiths K, Metcalfe NB, Monaghan P. Telomere length in early life predicts lifespan. Proc Natl Acad Sci U S A. 2012;109(5):1743-1748. doi:10.1073\/pnas.1113306109 \u003cbr\u003e\u003cbr\u003e5. Fu TT, Shen L. Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases. Front Pharmacol. 2022;13:850813. Published 2022 Mar 18. doi:10.3389\/fphar.2022.850813 \u003cbr\u003e\u003cbr\u003e6. Smith E, Ottosson F, Hellstrand S, et al. Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. Heart. 2020;106(9):691-697. doi:10.1136\/heartjnl-2019-315485 \u003cbr\u003e\u003cbr\u003e7. Wu LY, Kan CN, Cheah IK, et al. Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics. Antioxidants (Basel). 2022;11(9):1717. Published 2022 Aug 30. doi:10.3390\/antiox11091717 \u003cbr\u003e\u003cbr\u003e8. Ishimoto T, Kato Y. Ergothioneine in the brain. FEBS Lett. 2022;596(10):1290-1298. doi:10.1002\/1873-3468.14271 \u003cbr\u003e\u003cbr\u003e9. Fovet T, Guilhot C, Delobel P, Chopard A, Py G, Brioche T. Ergothioneine Improves Aerobic Performance Without Any Negative Effect on Early Muscle Recovery Signaling in Response to Acute Exercise. Front Physiol. 2022;13:834597. Published 2022 Feb 9. doi:10.3389\/fphys.2022.834597 \u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-how-it-work-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003eErgothioneine is an amino acid that your body is unable to make on its own but can be obtained from eating foods such as certain types of mushrooms and organ meat.\u003c\/li\u003e\n\u003cli\u003eAs you age, levels of ergothioneine decline in the body, potentially contributing to a decline in cellular, brain, heart, and muscle health.\u003c\/li\u003e\n\u003cli\u003eErgothioneine is absorbed in the small intestine and transported throughout the body via a specific transporter known as the Organic Cation Transporter 1 (OCTN1). This transporter is highly selective for ergothioneine, allowing it to enter cells efficiently.\u003c\/li\u003e\n\u003cli\u003eOnce inside the cells, ergothioneine primarily exerts its effects as a potent antioxidant. It works by donating electrons to neutralize harmful free radicals and reactive oxygen species (ROS) that are generated during normal cellular metabolism and in response to environmental stressors.\u003c\/li\u003e\n\u003cli\u003eAdministration of ergothioneine in animal studies has been shown to reduce oxidative stress, mediate inflammatory markers, and promote cellular, brain, and heart health.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServing Size: 1 Capsule\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"smalltext\"\u003eL-Ergothioneine\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e25 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\nREV.08.25\u003cbr\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eHypromellose (capsule), rice flour.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE:\u003c\/strong\u003e Take (1) capsule per day, with or without food.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION:\u003c\/strong\u003e For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"summary-copy\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnique Formulation. \u003c\/strong\u003eCompared to the majority of products on the market with lower doses, ProHealth's Ergothioneine contains a clinically effective dose of 25 mg of ergothioneine per serving.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuality Manufacturing Practices.\u003c\/strong\u003e All of our products are manufactured in an FDA-registered, GMP-certified facility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThird-Party Tested in the USA.\u003c\/strong\u003e Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Longevity","offers":[{"title":"Default Title","offer_id":51689883861358,"sku":"PH646C","price":101.87,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0206\/3076\/5668\/files\/PH646C_175ML_FRNT_600x600_0825.png?v=1780598655","url":"https:\/\/www.prohealth.com\/en-ae\/products\/prohealth-l-ergothioneine-25-mg-30-capsules-3-pack-ph646c","provider":"ProHealth.com","version":"1.0","type":"link"}