{"product_id":"prohealth-nmnr-pro-synergy-90-capsules-ph660","title":"NMNR™ Pro Synergy - 90 capsules","description":"\u003cdiv class=\"product-benefits-copy\" style=\"text-align: left;\"\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eFinally, NMN and NR Together\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNMN and NR elevate NAD+ through complementary pathways*\u003csup\u003e1,2\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003ePowers cellular energy to support brain, heart, and whole-body vitality*\u003csup\u003e3-5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eEnhances mitochondrial performance and resilience with age*\u003csup\u003e3-5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eIncludes TMG to support balanced methylation*\u003csup\u003e6\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eAddresses key drivers of healthy aging*\u003csup\u003e2,7\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"color: #0000ff;\"\u003e\u003ca style=\"color: #0000ff;\" rel=\"noopener noreferrer\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0206\/3076\/5668\/files\/PH660_-_COA_Certified_LOT_2509141_2025-11-25.pdf?v=1764630672\" target=\"_blank\"\u003eView Certificate of Analysis\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eThe Next Evolution in NAD+ Science \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNMNR™ Pro Synergy unites NMN and NR in one advanced formula designed to restore and sustain cellular NAD+ levels. This dual-precursor approach fuels energy production, supports DNA repair, and promotes cellular revitalization. With added TMG to maintain methylation balance, the formula delivers comprehensive, long-term support for healthy aging and vitality.*\u003csup\u003e1-7\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eHow It Works \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis formula is designed to help restore NAD+ through three complementary mechanisms.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNMN (Nicotinamide Mononucleotide)\u003c\/strong\u003e \u003cbr\u003eNMN is an immediate precursor to NAD+ that bypasses early rate-limiting steps in the salvage pathway. It supports rapid increases in intracellular NAD+, helping energize mitochondria and activate sirtuin enzymes involved in cellular repair and longevity.*\u003csup\u003e3,4\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNR (Nicotinamide Riboside)\u003c\/strong\u003e\u003cbr\u003eNR complements NMN by supporting systemic NAD+ synthesis through distinct transport and conversion pathways. Hydrogen malate enhances NR bioavailability and provides malic acid, a key component of the Krebs energy cycle.*\u003csup\u003e2,8\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTrimethylglycine (TMG) \u003c\/strong\u003e\u003cbr\u003eTMG provides methyl groups needed to recycle homocysteine into methionine, supporting balanced methylation and maintaining NAD+ homeostasis. It also protects against the potential depletion of methyl donors during NAD+ synthesis from NMN and NR.*\u003csup\u003e6\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTogether, these clinically studied ingredients help restore healthy NAD+ levels and strengthen the body’s natural capacity for energy, repair, and resilience.*\u003csup\u003e1-5 \u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhy NAD+ Matters \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNicotinamide Adenine Dinucleotide (NAD) is a vital coenzyme present in every cell, essential for creating and maintaining energy throughout the body. Each human cell contains hundreds of millions of NAD+ molecules that power metabolism, drive DNA repair, and activate key enzymes like PARPs and sirtuins, which sustain cellular integrity, stress resilience, and healthy aging.\u003csup\u003e9,10\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eAs we age, NAD+ levels naturally decline. This reduction diminishes mitochondrial energy production and weakens the activity of sirtuins, PARPs, and AMPK, leaving cells more susceptible to damage. The decline is further accelerated by increased CD38 activity — an enzyme that degrades NAD+ and disrupts energy balance.\u003csup\u003e9,10\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003eRestoring NAD+ levels with precursors such as NMN and NR, complemented by TMG for methylation support, helps sustain cellular energy production and preserve healthy NAD+ metabolism over time.*\u003csup\u003e6,9,10\u003c\/sup\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eWhat Makes Ours Better?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDual-Pathway NAD+ Support:\u003c\/strong\u003e Combines NMN and NR to enhance both intracellular and systemic NAD+ synthesis.*\u003csup\u003e1,2\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMethylation-Enhanced:\u003c\/strong\u003e Includes 300 mg TMG per serving to maintain methylation balance and support healthy clearance of NAD+ metabolites.*\u003csup\u003e6\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargeted Liver Support:\u003c\/strong\u003e Supplies key nutrients that drive hepatic detoxification and help restore balance.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Supported Dosing:\u003c\/strong\u003e Delivers 1000 mg of NAD+ precursors per serving, reflecting levels used in human studies demonstrating improvements in cellular and metabolic function.*\u003csup\u003e3-5\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynergistic Design:\u003c\/strong\u003e Developed to activate multiple longevity mechanisms — from NAD+ synthesis and recycling to sirtuin and AMPK activation.*\u003csup\u003e10\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eThe ProHealth Difference\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDoctor-Formulated:\u003c\/strong\u003e Developed by our in-house science team in collaboration with leading wellness experts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTriple Lab Tested:\u003c\/strong\u003e Verified three times by independent labs for purity and potency.\u003c\/li\u003e\n\u003cli\u003e \u003cstrong\u003eFull Transparency:\u003c\/strong\u003e Third-party test results published online for complete confidence.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUSA Manufactured:\u003c\/strong\u003e Proudly manufactured in the USA in FDA-registered, GMP-certified facilities since 1988.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e100-Day Risk-Free Guarantee:\u003c\/strong\u003e If you’re not fully satisfied, we’ll refund your purchase in full.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eA Word from our Chief Science Officer\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\"People tend to fall into camp NMN or camp NR. But why not do both? These two forms of vitamin B3 act at different points in the NAD+ pathway, working together to sustain NAD+ levels across multiple tissues. Used in combination, they provide broader support for the entire NAD+ metabolome.\"\u003c\/p\u003e\n\u003cp\u003e\u003cstrong style=\"font-size: 1.1em;\"\u003eIngredient Info\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNicotinamide Mononucleotide (NMN):\u003c\/strong\u003e A vitamin B3 derivative and essential precursor in the NAD+ production pathway.* \u003cbr\u003e\u003cstrong\u003eNicotinamide Riboside (NR):\u003c\/strong\u003e A vitamin B3 derivative and essential precursor in the NAD+ production pathway.* \u003cbr\u003e\u003cstrong\u003eTrimethylglycine (TMG):\u003c\/strong\u003e A natural methyl donor that supports NAD+ metabolism and maintains homocysteine balance.*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eHuang H. \u003cem\u003eFront Aging\u003c\/em\u003e. 2022;3:851698.\u003c\/li\u003e\n\u003cli\u003eOrr ME et al. \u003cem\u003eGeroScience\u003c\/em\u003e. 2024;46(1):665-682.\u003c\/li\u003e\n\u003cli\u003eKim M et al. \u003cem\u003eNutrients\u003c\/em\u003e. 2022;14(4):755.\u003c\/li\u003e\n\u003cli\u003eJanssens GE et al. \u003cem\u003eNat Aging\u003c\/em\u003e. 2022;2(3):254-263.\u003c\/li\u003e\n\u003cli\u003eNascimento EBM et al. \u003cem\u003eJ Clin Endocrinol Metab\u003c\/em\u003e. 2021;106(5):1437-1447.\u003c\/li\u003e\n\u003cli\u003eArumugam MK et al. \u003cem\u003eBiology\u003c\/em\u003e. 2021;10(6):456.\u003c\/li\u003e\n\u003cli\u003eYi L et al. \u003cem\u003eGeroScience.\u003c\/em\u003e 2023;45(1):29-43.\u003c\/li\u003e\n\u003cli\u003eMehmel M et al. \u003cem\u003eNutrients\u003c\/em\u003e. 2020;12(6):1616.\u003c\/li\u003e\n\u003cli\u003eRadenkovic D et al. \u003cem\u003ePharmaceuticals (Basel)\u003c\/em\u003e. 2020;13(9):247.\u003c\/li\u003e\n\u003cli\u003eLópez-Otín C et al. \u003cem\u003eCell\u003c\/em\u003e. 2023;186(2):243-278.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"product-label-copy\"\u003e\n\u003ctable style=\"height: 177.333px;\" width=\"100%\" cellspacing=\"2\" cellpadding=\"0\" border=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 20.5333px;\"\u003e\n\u003cth colspan=\"3\" style=\"font-size: 11pt; font-weight: bold; height: 20.5333px;\" align=\"left\"\u003eSupplement Facts\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" colspan=\"3\" class=\"smalltext\"\u003eServing Size: 3 Capsules\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" colspan=\"3\" class=\"smalltext\"\u003eServings Per Container: 30\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd colspan=\"2\" class=\"smalltext\" style=\"font-weight: bold; height: 19.6px;\"\u003eAmount Per Serving\u003c\/td\u003e\n\u003ctd style=\"white-space: nowrap; height: 19.6px;\" class=\"smalltext\" align=\"right\"\u003e\u003cstrong\u003e%DV\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" class=\"smalltext\"\u003eNicotinamide Mononucleotide (NMN)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\" align=\"right\"\u003e500 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 39.2px;\"\u003e\n\u003ctd style=\"height: 39.2px;\" class=\"smalltext\"\u003eNicotinamide Riboside\u003cbr\u003e  (as NR Hydrogen Malate)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap; height: 39.2px;\" align=\"right\"\u003e500 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap; height: 39.2px;\" align=\"right\"\u003e†\u003cbr\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" class=\"smalltext\"\u003eTrimethylglycine (TMG)\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\" align=\"right\"\u003e300 mg\u003c\/td\u003e\n\u003ctd class=\"smalltext\" style=\"white-space: nowrap; height: 19.6px;\" align=\"right\"\u003e†\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6px;\"\u003e\n\u003ctd style=\"height: 19.6px;\" colspan=\"3\" class=\"smalltext\"\u003e† Daily Value (DV) not established\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eREV.09.25\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOTHER INGREDIENTS: \u003c\/strong\u003eHypromellose (capsule), rice flour.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSUGGESTED DAILY USE: \u003c\/strong\u003eTake three (3) capsules per day, with or without food, preferably in the morning.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAUTION: \u003c\/strong\u003eFor use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. \u003cstrong\u003eKEEP OUT OF REACH OF CHILDREN\u003c\/strong\u003e. Store in a cool and dry place after opening.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"ProHealth Longevity","offers":[{"title":"Default Title","offer_id":52970623336814,"sku":"PH660","price":35.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0206\/3076\/5668\/files\/PH660_FRNT_250CC_600x600-REV0925.png?v=1763508429","url":"https:\/\/www.prohealth.com\/en-ae\/products\/prohealth-nmnr-pro-synergy-90-capsules-ph660","provider":"ProHealth.com","version":"1.0","type":"link"}