OBJECTIVE. As disturbed nociception may be relevant to the
pathogenesis of fibromyalgia, nonnoxious electrocutaneous
stimulation was used as a tool to investigate nociceptive
METHODS. Perception threshold and pain tolerance were
studied in the upper limbs of 10 patients with fibromyalgia
and 10 healthy volunteers.
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RESULTS. Perception threshold did
not differ between the groups but the marked reduction in pain
tolerance found in patients with fibromyalgia was accompanied
by spread and persistence of dysesthesiae.
upper limbs of patients with fibromyalgia resembled regions of
secondary hyperalgesia, which may imply that perturbation of
central nociceptive mechanisms is involved in the pathogenesis
of this syndrome.
Arroyo JF, Cohen ML