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Clinical Trials Recruiting Participants

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As yesterday’s article Clinical Trials reported, clinical trials play an important role in research and add to medical knowledge. Clinical trials are an important part of fibromyalgia research, and at any given time, there are hundreds of clinical trials being conducted. A quick review of the U.S. National Institutes of Health website,, includes the following trials currently recruiting trial subjects.

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain. Health disparities, or health outcomes that adversely affect disadvantaged populations, are pervasive and apparent in many diseases and symptoms, including pain.

If successful, this work will form the foundation of a new research program that will link the field of pain research with the field of social neuroscience, and forge new insights on the critical problem of health disparities in pain.

Effects of External Ear Stimulation on Pain Perception and Mood
This double-blind, randomized, controlled, cross-over study on healthy participants will evaluate the perceptual differences of pain and changes in mood in response to peripheral nerve stimulation over two regions of the left external ear. A series of short and long duration heat stimuli will be applied to the participants’ forearms and they will be asked to rate their current mood state, the intensity of the pain, and whether it was pleasant or unpleasant. The series of heat stimuli will be applied before, during, and after mild electrical stimulation of the left external ear using a commercially available TENS unit. There are two study sessions.

Clinical and Scientific Assessment of Pain and Painful Disorders
The purpose of this study is to allow for the deep, broad, and targeted phenotyping of persons with or without pain disorders. The specific goals of this protocol includes facilitation of information gathering and performance of descriptive analyses of painful experiences within discrete pain disorders.

Exercise Maintenance in Chronic Pain and PTSD
This study will compare the effects of a 3-month, individually prescribed progressive exercise training program on: 1) chronic low back pain (cLBP), depression and PTSD symptoms, and 2) neurobiological and related neuropsychological mechanisms by which our exercise-training paradigm may foster exercise maintenance.

Merging Yoga and Self-Management to Develop Skills (MY-SKILLS)
The long-term goal of this study is to advance best practices in complementary and integrative health (CIH) to improve health for caregivers and individuals with chronic disabilities. This proposal is focused on merging exercise and education to improve pain for individuals in a caregiving dyad.

Effects of Behavioral Interventions on Mechanisms of Pain Regulation and Hedonic Regulation
The overarching aim of this project is to conduct a randomized controlled study to determine whether Mindfulness-Oriented Recovery Enhancement (MORE) vs. a Support Group (SG) can improve pain regulation and hedonic functions (i.e., natural reward responsiveness) thought to be governed by the endogenous opioid system among opioid-treated, chronic, non-neuropathic back pain patients (CNBP) and thereby improve clinical pain, affect, and opioid use.

Brain Mechanisms of Psychosocial Aspects of Acupuncture Therapy
The overall aim of the study is to investigate how patients’ and clinicians’ (Licensed acupuncturists, LAc) neural and autonomic processes during treatment interaction correlate to patient outcomes. Male and female healthy clinicians and fibromyalgia patients will be recruited for the study.

Neuroimaging Approaches to Deconstructing Acupuncture for Chronic Pain
The aim of this study is to evaluate the impact of electro-acupuncture in pain processing on patients with fibromyalgia (FM). The investigators hypothesize that electro-acupuncture is effective for FM because it functions as a desensitization therapy, which when applied repeatedly over multiple treatment sessions, gradually habituates the nervous system to continuing pain and sensory signaling.

Remember:  Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about clinical studies, you or your doctor may contact the study research staff using the Contacts provided in each description. For general information, see Learn About Clinical Studies.

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