25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey – Source: Atherosclerosis, Nov 11, 2008

Objective: Serum 25-hydroxyvitamin D [25(OH)D] levels are inversely associated with important cardiovascular disease (CVD) risk factors. [Higher D levels, lower incidence of risk factors.] However, the association between 25(OH)D levels and prevalent CVD has not been extensively examined in the general population.

Methods: We performed a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey (1988-1994) and examined the association between serum 25(OH)D levels and prevalence of CVD in a representative population-based sample of 16,603 men and women aged 18 years or older. Prevalence of CVD was defined as a composite measure inclusive of self-reported angina, myocardial infarction or stroke.

Results: In the whole population, there were 1,308 (8%) subjects with self-reported CVD. Participants with CVD had a greater frequency of 25(OH)D deficiency [defined as serum 25(OH)D levels <20ng/mL] than those without (29.3% vs. 21.4%; p<0.0001). After adjustment for age, gender, race/ethnicity, season of measurement, physical activity, body mass index, smoking status, hypertension, diabetes, elevated low-density lipoprotein cholesterol, hypertriglyceridemia, low high-density lipoprotein cholesterol, chronic kidney disease and vitamin D use, participants with 25(OH)D deficiency had an increased risk of prevalent CVD (odds ratio 1.20 [95% confidence interval (CI) 1.01-1.36; p=0.03]). [Note: an odds ratio of 1.0 indicates no difference. An OR of 1.20 indicates the vitamin D deficient group is 20% more likely to have CVD, independent of the other risk factors listed.]

Conclusions: These results indicate a strong and independent relationship of 25(OH)D deficiency with prevalent CVD in a large sample representative of the US adult population.

Source: Atherosclerosis, Nov 11, 2008 [E-pub ahead of print] PMID: 19091317, by Kendrick J, Targher G, Smits G, Chonchol M. Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, USA. [E-mail:

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