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A 57-year-old Japanese male developed erythema migrans, arthralgia, and neurological symptoms after mountain climbing in Nagano Prefecture. On ELISA, his serum reacted to Borrelia isolated from various sources. The patient’s serum reacted with a 41 kilodalton protein which was reactive with monoclonal antibody H9724 specific to flagellin of Borrelia on Western blotting. He recovered after taking minocycline 200 mg daily for 2 weeks.