A case with Chronic Fatigue Syndrome with positive antinuclear antibody followed by postpartum thyroiditis

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[Note: antinuclear antibodies (ANAs) are a type of “auto-antibody” – detectable in the blood and directed against the body’s own tissues. Thyroiditis is an inflammation of the thyroid gland.] Journal: Modern Rheumatology. 2004 Nov;14(5):406-9. Authors: Itoh Y, Hamada H, Igarashi T, Kuwabara N, Imai T, Fujino O, Fukunaga Y. Department of Pediatrics, Nippon Medical School, Tokyo, Japan. [E-mail: yasuhiko@nms.ac.jp ] PMID: 17143702

Autoimmune Fatigue Syndrome (AIFS) is defined by chronic nonspecific complaints, a positive antinuclear antibody (ANA) assay, and the absence of another explanation for the complaints. Some severe cases fulfill the criteria for Chronic Fatigue Syndrome (CFS). CFS is a syndrome characterized by disabling severe fatigue and defined by the criteria proposed by the U.S. Centers for Disease Control and Prevention.

In this report, a patient with Chronic Fatigue Syndrome and positive ANA assay was described as having developed postpartum thyroiditis 5 years after the onset. Subchemical hypothyroidism is characterized by clinical hypothyroidism not meeting biochemical criteria but showing evidence of thyroid autoimmunity. The relation between AIFS and subchemical hypothyroidism is discussed.

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