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A Preliminary Comparative Assessment of the Role of CD8+T Cells in Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis and Multiple Sclerosis

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By Ekua W Brenu et al.
 
Abstract: Background CD8+T cells have putative roles in the regulation of adaptive immune responses during infection. The purpose of this paper is to compare the status of CD8+T cells in Multiple Sclerosis (MS) and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).
 
Methods: This preliminary investigation comprised of 23 CFS/ME patients, 11 untreated MS patients and 30 non-fatigued controls. Whole blood samples were collected from participants, stained with monoclonal antibodies and analysed on the flow cytometer. Using the following CD markers, CD27 and CD45RA (CD45 exon isoform 4), CD8+T cells were divided into naïve, central memory (CM), effector memory CD45RA- (EM cells) and effector memory CD45RA+ (EMRA) cells.
 
Results: Surface expression of BTLA, CD127 and CD49/CD29 were increased on subsets of CD8+T cells from MS patients. In the CFS/ME patients CD127 was significantly decreased on all subsets of CD8+T cells in comparison to the non-fatigued controls. PSGL-1 was significantly reduced in the CFS/ME patients in comparison to the non-fatigued controls.
 
Conclusions: The results suggest significant deficits in the expression of receptors and adhesion molecules on subsets of CD8+T cells in both MS and CFS/ME patients. These deficits reported may contribute to the pathogenesis of these diseases. However, larger sample size is warranted to confirm and support these encouraging preliminary findings.
 
Source: Ekua W Brenu, Simon Broadley, Thao Nguyen, Samantha Johnston, Sandra Ramos, Don Staines, Sonya Marshall- Gradisnik. A Preliminary Comparative Assessment of the Role of CD8+T Cells in Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis and Multiple Sclerosis.  Journal of Immunology Research. December 15, 2015.

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