A two-year-old male Pointer had been presented with anorexia, cachexia, and weight loss of 10-day duration. Upon physical examination, fever, lethargy, superficial lymph node enlargement, and tick infestation were noted. The only abnormality in CBC and serum chemistry analyses was mild hyperglobulinemia. Spleen was enlarged by radiography, and the lymph nodes showed neutrophilic lymphadenitis by cytological examination. A polymerase chain reaction test for babesiosis and commercial ELISA tests for Ehrlichia canis, heartworm, and
Lyme disease was negative except for
Lyme disease, which was verified by both an IFA-IgG test and a quantitative C(6) assay. Doxycycline was administered for 2 weeks and the recovery was uneventful. Post-treatment C(6) titer decreased to within normal limits.