A two-year follow-up study of chronic fatigue syndrome comorbid with psychiatric disorders – Source: Psychiatry and Clinical Neurosciences, Jun 2009

Aims: Chronic fatigue syndrome patients often have comorbid psychiatric disorders such as major depressive disorders and anxiety disorders. However, the outcomes of chronic fatigue syndrome and the comorbid psychiatric disorders and the interactions between them are unknown.

Therefore, a two-year prospective follow-up study was carried out on chronic fatigue syndrome patients with comorbid psychiatric disorders.

Methods: A total of 155 patients who met the Japanese case definition of chronic fatigue syndrome were enrolled in this study. Comorbid psychiatric disorders were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition criteria.

Patients with comorbid psychiatric disorders received psychiatric treatment in addition to medical therapy for chronic fatigue syndrome. Seventy patients participated in a follow-up interview approximately 24 months later.

Results: Of the 70 patients with chronic fatigue syndrome, 33 patients were diagnosed as having comorbid psychiatric disorders including 18 major depressive disorders.

Sixteen patients with psychiatric disorders and 8 patients with major depressive disorders did not fulfill the criteria of any psychiatric disorders at the follow up.

As for chronic fatigue syndrome, 9 out of the 70 patients had recovered at the follow up. There is no significant influence of comorbid psychiatric disorders on the outcome of chronic fatigue syndrome.


Chronic fatigue syndrome patients have a relatively high prevalence of comorbid psychiatric disorders, especially major depressive disorders.

The outcomes of chronic fatigue syndrome and psychiatric disorders are independent.

Therefore treatment of comorbid psychiatric disorders is necessary in addition to the medical treatment given for chronic fatigue syndrome.

Source: Psychiatry and Clinical Neurosciences, Jun 2009;63(3):365-73. PMID: 19566769, by Matsuda Y, Matsui T, Kataoka K, Fukada R, Fukuda S, Kuratsune H, Tajima S, Yamaguti K, Kato YH, Kiriike N. Department of Neuropsychiatry, Osaka City University Graduate School of Medicine, Osaka, Japan. [E-mail: mackham10@yahoo.co.jp]

1 Star2 Stars3 Stars4 Stars5 Stars (36 votes, average: 3.30 out of 5)

One thought on “A two-year follow-up study of chronic fatigue syndrome comorbid with psychiatric disorders – Source: Psychiatry and Clinical Neurosciences, Jun 2009”

  1. gkb440 says:

    treatment for depression when you have me cfs fms mcs creates major problems
    people with me cfs fms mcs cannot tolerate depressions drugs like
    zyppreza,seraquel lovan advanza or any other ssri lithum and many more that have been jammed down my throat
    27 ect’s were carried out before they said this isnt working
    suffering severe mcs fms and me the effects of this treatment just make me so sick i cant get out of bed
    misdiagnosed with bi polar this amounts to medical malpratice
    i have refused to take anymore
    i am now bieing told i will be sectioned and placed in a mental hospital if i dont take this zypreza and seraquel

Leave a Reply