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Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice.

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Abstract

The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute
Lyme arthritis. These results contrasted with the reduction of
Lyme arthritis by IL-12 antibodies in immunocompetent animals. These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an exacerbation of joint inflammation.

Infect Immun. 1997 Oct;65(10):4334-6. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.

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