Abstract: Amyloid beta and Alzheimer disease therapeutics: the devil may be in the details

J Clin Invest. 2003 Aug;112(3):321-3.

Comment on:

J Clin Invest. 2003 Aug;112(3):415-22.

J Clin Invest. 2003 Aug;112(3):440-9.

Cirrito JR, Holtzman DM.

Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Alzheimer disease (AD) is characterized by the progressive accumulation of amyloid beta protein (Abeta) in areas of the brain serving cognitive functions such as memory and language. The first of two separate reports (see the related articles beginning on pages 415 and 440) reveals that intrinsic T cell reactivity to the self-antigen Abeta exists in many humans and increases with age. This finding has implications for the design of Abeta vaccines. The second report demonstrates that a number of FDA- approved nonsteroidal anti-inflammatory drugs are capable of lowering Abeta levels in mice. The work suggests that further testing of the therapeutic utility of these types of compounds for the potential treatment of AD is warranted.

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PMID: 12897198 [PubMed – indexed for MEDLINE]

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