Abstract: Anti-glutamic acid decarboxylase antibodies in a patient with systemic lupus erythematosus and fibromyalgia symptoms

Lupus. 2005;14(6):486-8.

Taylor-Gjevre RM, Gjevre JA.

Division of Rheumatology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada. r.gjevre@usask.ca

We report the case of a 29-year old female nurse with a five-year history of systemic lupus erythematosus (SLE) involving multiple systems and on chronic prednisone therapy. This patient has a coexisting diagnosis of fibromyalgia fulfilling ACR criteria. A recent deterioration in her level of functioning in addition to a flare of her inflammatory disease led to further evaluation. During the course of investigation an anti-glutamic acid decarboxylase antibody was found to be present and significantly elevated. A therapeutic trial of baclofen did result in improvement of her subjective myalgias. We raise the possibility of an autoimmune contribution to myalgic symptoms in a portion of SLE patients.

PMID: 16038114 [PubMed – in process]

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