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Abstract: Brain 5-HT(1A) receptor binding in chronic fatigue syndrome measured using positron emission tomography and [(11)C]WAY-100635

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Biol Psychiatry. 2005 Feb 1;57(3):239-46.

Cleare AJ, Messa C, Rabiner EA, Grasby PM.

Section of Neurobiology of Mood Disorders, Division of Psychological Medicine, Institute of Psychiatry and Guy-s, King-s and St. Thomas- School of Medicine; National Affective Disorders Unit, Bethlem Royal and Maudsley Hospitals.

BACKGROUND: Research from neuroendocrine challenge and other indirect studies has suggested increased central 5-HT function in chronic fatigue syndrome (CFS) and increased 5-HT(1A) receptor sensitivity.
We assessed brain 5-HT(1A) receptor binding potential directly using the specific radioligand [(11)C]WAY-100635 and positron emission tomography (PET).

METHODS: We selected 10 patients from a tertiary referral clinic who fulfilled the CDC consensus criteria for CFS. To assemble a homogenous group and avoid confounding effects, we enrolled only subjects who were completely medication-free and did not have current comorbid psychiatric illness. We also scanned 10 healthy control subjects.

RESULTS: There was a widespread reduction in 5-HT(1A) receptor binding potential in CFS relative to control subjects. This was particularly marked in the hippocampus bilaterally, where a 23% reduction was observed.

CONCLUSIONS: There is evidence of decreased 5-HT(1A) receptor number or affinity in CFS. This may be a primary feature of CFS, related to the underlying pathophysiology, or a finding secondary to other processes, such as previous depression, other biological changes or the behavioral consequences of CFS.

PMID: 15691524 [PubMed – in process]

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