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Abstract: Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells

J Clin Immunol 2003 Mar;23(2):141-5

Aoukaty A, Lee IF, Wu J, Tan R.

Department of Pathology & Laboratory Medicine, British Columbia’s Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V4.

Chronic active Epstein-Barr virus (CAEBV) infection is an uncommon and severe manifestation of EBV infection that frequently leads to the development of natural killer (NK) or T cell lymphomas. We report here that NK cells derived from a boy with CAEBV showed decreased cytotoxic function and impaired interferon-gamma secretion against a variety of transformed target cell lines. In addition, NK cells from the patient lacked expression of the broadly expressed NK receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). These data suggest that CAEBV is associated with low expression of LAIR-1 on NK cells.

PMID: 12757266 [PubMed – in process]