Abstract: Effect of vitamin E on carotid artery elasticity and baroreflex gain in young, healthy adults

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Auton Neurosci. 2004 Jun 30;113(1-2):63-70.

Studinger P, Mersich B, Lenard Z, Somogyi A, Kollai M.

Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Faculty of Medicine, H-1446 Budapest, P.O. Box 448, Hungary.

In this study we tested the hypothesis that dietary vitamin E supplementation can improve carotid artery elasticity and cardio-vagal baroreflex gain in young, healthy individuals. A total of 20 subjects were studied in a double-blind, placebo-controlled, randomized study. Subjects in the active treatment group received 700 IU/day vitamin E for 1 month.

Each subject was studied three times: before, during and 1 month after treatment. Plasma vitamin E levels were determined using high-performance liquid chromatography. Carotid artery diameter was measured by ultrasound and radial artery pressure by tonometry. Baroreflex function was assessed by time and frequency domain spontaneous indices. Plasma vitamin E levels increased by 123%, which was associated with a 20% increase in carotid artery compliance and a 30-60% increase in baroreflex indices.

All these changes regressed 1 month after cessation of vitamin E supplementation. Significant correlations were observed across conditions (control, treatment and recovery), among plasma vitamin E concentrations, carotid artery compliance and distensibility values and two of the baroreflex gain indices in the treatment group. Our results demonstrate that vitamin E supplementation can increase carotid artery compliance and baroreflex gain in young, apparently healthy adults.

PMID: 15296796 [PubMed – in process]

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