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Abstract: Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder

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Journal: Ann N Y Acad Sci 2001 Mar;933:323-9

Authors: Pall ML, Satterle JD.

Affiliation: School of Molecular Biosciences, Washington State University, Pullman 99164-4660, USA. mailto:martin_pall@wsu.edu

NLM Citation: PMID: 12000033

Various types of evidence implicate nitric oxide and an oxidant, possibly peroxynitrite, in MCS and chemical intolerance (CI).

The positive feedback loops proposed earlier for CFS may explain the chronic nature of MCS (CI) as well as several of its other reported properties.

These observations raise the possibility that this proposed elevated nitric oxide/peroxynitrite mechanism may be the mechanism of a new disease paradigm, answering the question raised by Miller earlier: “Are we on the threshold of a new theory of disease?”

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