Abstract: GBV-C – a virus without a disease: We cannot give it chronic fatigue syndrome

BMC Infect Dis. 2005 Sep 28;5(1):78 [Epub ahead of print]

Jones JF, Kulkarni PS, Butera ST, Reeves WC.

BACKGROUND: Chronic fatigue syndrome (CFS) is an illness in search of an infectious etiology. GBV-C virus is a flavivirus with cell tropism and host defense induction qualities compatible with a role in producing the syndrome. The GBV-C genome is detectable in 4% of the population and 12% of the population is seropositive. The present study evaluated the association between infection with GBV and CFS.

METHODS: We used a commercial EIA to detect antibodies against the GBV-C E2 protein and a quantitative real-time RT-PCR assay to detect active GBV-C infection. Sera were from a case control study of CFS in Atlanta, Georgia. The Fisher’s exact two-tailed test was used for statistical analysis.

RESULTS: Two of 12 CFS patients and one of 21 controls were seropositive for prior GBV-C infection and one control had viral RNA detected, indicating active infection. The results are not statistically different.

CONCLUSIONS: We found no evidence that active or past infection with GBV is associated with CFS.

PMID: 16191201 [PubMed – as supplied by publisher]

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