J Lipid Res. 2003 Sep 1 [Epub ahead of print].
Alzheimers disease (AD) is characterized by deposition of -amyloid (A ) plaques derived from amyloidogenic processing of a transmembrane -amyloid precursor protein (APP). Besides the known genetic/sporadic factors that promote the formation of A, composition and structural dynamics of the membrane also are implicated to play a significant role in the amyloidogenic processing of APP that seeds A. This mini-review reinforces the roles played by membrane dynamics, membrane-microdomains and cholesterol homeostasis in relation to amyloidogenesis, and reviews current strategies of lowering cholesterol in treating Alzheimers disease.
PMID: 12951356 [PubMed – as supplied by publisher]