Abstract: Pathogenic mechanisms of fibromyalgia

Ageing Res Rev 2002 Apr;1(2):243-55

Neeck G.

Department of Rheumatology, Kerckhoff Clinic and

Foundation, University of Giessen, Ludwigstrasse

37-39, 61231, Bad Nauheim, Germany

PMID: 12039441


COMPRISES THREE SYSTEMS: the musculoskeletal system

with widespread muscular pain, neuroendocrine

disorders, and psychological distress including

anxiety and depression.

Fibromyalgia is predominantly found in middle aged

women. Though the most prominent symptom of

fibromyalgia is pain in defined regions of the

locomotor system, the numerous other somatoform and psychological disorders suppose a common primary disturbance which is considered to originate within higher levels of the central nervous system.

Studies of the entire endocrine profile of

fibromyalgia patients support the hypothesis that an

elevated activity of corticotropin releasing hormone

(CRH) neurons determines not only many symptoms of

fibromyalgia but may also cause alterations observed

in the hormonal axes. Hypothalamic CRH neurons thus

may play a key role not only in resetting the various

endocrine loops but possibly also nociceptive and

psychological mechanisms as well.

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