Ageing Res Rev 2002 Apr;1(2):243-55
Department of Rheumatology, Kerckhoff Clinic and
Foundation, University of Giessen, Ludwigstrasse
37-39, 61231, Bad Nauheim, Germany
THE SYMPTOMATOLOGY CHARACTERIZING FIBROMYALGIA
COMPRISES THREE SYSTEMS: the musculoskeletal system
with widespread muscular pain, neuroendocrine
disorders, and psychological distress including
anxiety and depression.
Fibromyalgia is predominantly found in middle aged
women. Though the most prominent symptom of
fibromyalgia is pain in defined regions of the
locomotor system, the numerous other somatoform and psychological disorders suppose a common primary disturbance which is considered to originate within higher levels of the central nervous system.
Studies of the entire endocrine profile of
fibromyalgia patients support the hypothesis that an
elevated activity of corticotropin releasing hormone
(CRH) neurons determines not only many symptoms of
fibromyalgia but may also cause alterations observed
in the hormonal axes. Hypothalamic CRH neurons thus
may play a key role not only in resetting the various
endocrine loops but possibly also nociceptive and
psychological mechanisms as well.