Rheumatology Advance Access published July 30, 2003, 10.1093/rheumatology/keg362
Rheumatology 2003; 42: 1234-1241
© 2003 British Society for Rheumatology
R. M. Nagler1,2, F. Salameh1,3, A. Z. Reznick2, V. Livshits3 and A. M. Nahir3
1Oral Biochemistry Laboratory and Salivary Clinic, Department of Oral and Maxillofacial Surgery, 2Department of Anatomy and Cell Biology and 3B. Shine Department of Rheumatology, Rambam Medical Center and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Correspondence to: R. M. Nagler, Department of Oral and Maxillofacial Surgery, Rambau Medical Center, Haifa 31096, Israel. E-mail: email@example.com
Objectives. The objective of the present study was to analyse salivary gland and free radical involvement in rheumatoid arthritis (RA).
Methods. Thirty-four consenting RA patients (rheumatoid factor-positive) and 18 healthy controls, matched in age and gender, participated in the study. Plasma and saliva samples were harvested and subjected to compositional analysis and various free radical-related tests.
Results. The mean salivary flow rate was lower in the RA patients than in the control group, whereas all plasma and salivary antioxidants were increased. Mean values of plasma malondialdehyde and ceruloplasmin were higher in the RA patients.
Conclusions. The effects of RA on salivary gland flow rates and antioxidant compositional parameters may be of great importance for the further elucidation of the role of free radicals in RA pathogenesis and for its general diagnosis and evaluation. The demonstrated correlation between the altered salivary parameters and the severity of the disease may indicate that evaluation of the salivary status of RA patients is warranted.
KEY WORDS: Saliva, Antioxidants, Rheumatoid arthritis, Total antioxidant status, Peroxidase, Uric acid, Malondialdehyde, Ceruloplasmin, Creatinine