Abstract: Serotonergic agents in the treatment of fibromyalgia syndrome

Ann Pharmacother 2002 Apr;36(4):707-12

Miller LJ, Kubes KL.

Lisa J Miller PharmD BCPP GCP, Clinical Pharmacy Specialist, Pharmacy Department, Memorial Hermann Southwest Hospital, Houston, TX.

PMID: 11918524

OBJECTIVE: To evaluate literature that discusses the treatment of fibromyalgia syndrome (FMS) with agents that involve the neurotransmitter serotonin.

DATA SOURCES: Biomedical literature accessed through MEDLINE (1966-August

2001) and International Pharmaceutical Abstracts. DATA

SYNTHESIS: The cause and pathophysiology of FMS remain elusive, although abnormalities in the serotonin pathway have been implicated. Several serotonergic agents have been studied for use in FMS. Trials and case reports focusing on the use of newer agents: the selective serotonin reuptake inhibitors, venlafaxine and tramadol, were reviewed.

CONCLUSIONS: Current research suggests that the serotonergic agents may reduce at least some of the symptoms of FMS. However, medications that act on multiple neurotransmitters may prove to be more effective in symptom management. Additional long-term studies are required in order to validate these results.

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