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Abstract: Synthesis of vitamin D in skin after burns

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Lancet. 2004 Jan 24;363(9405):291-2.

Klein GL, Chen TC, Holick MF, Langman CB, Price H, Celis MM, Herndon DN.

Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555-0352, USA. gklein@utmb.edu

Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.

PMID: 14751703 [PubMed – in process]

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