Drugs Today (Barc). 2004 Jun;40(6):539-54. Rao SG, Clauw DJ. Cypress Bioscience, San Diego, California, USA. firstname.lastname@example.org
Fibromyalgia is one of a number of overlapping "functional somatic syndromes," including irritable bowel syndrome, tension headache, chronic idiopathic lower back pain, chronic fatigue syndrome and others. These conditions affect females more frequently than males and probably share common underlying neurobiological mechanisms, as well as frequent psychological, cognitive and behavioral comorbidities.
Since the pain in these conditions is most likely "central" in origin, classes of drugs such as nonsteroidal antiinflammatory drugs (NSAIDs) and opioids, which are quite effective for "peripheral" pain, are relatively ineffective for the pain seen in these syndromes. Instead, tricyclic and other classes of antidepressants, antiseizure drugs and a number of other neuroactive compounds seem to be more effective. In addition, nonpharmacological therapies such as aerobic exercise and cognitive behavioral therapy are quite effective and frequently underutilized in clinical practice. (c) 2004 Prous Science. All rights reserved. PMID: 15349132 [PubMed – in process]