Abstract: [Two cases of infectious mononucleosis-like syndrome associated with human herpes-virus 6]

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Kansenshogaku Zasshi 2002 Jun;76(6):455-9

[Article in Japanese]

Tomita S, Takeda N, Isonuma H, Sato T, Ohshima H, Ebe T, Sekiya S, Matsumoto T, Hayashida Y, Watanabe K.

Department of General Medicine, Juntendo University School of Medicine.

We experienced two cases of infectious mononucleosis-like syndrome associated with human herpesvirus 6 (HHV-6). One of the patients had been under medication for depression and the other one for schizophrenia. Both of them were taking carbamazepine for more than a week along with the other drugs.

The manifestation of the symptoms of those two were almost same, such as high fever, generalized eruption, liver dysfunction, lymph-adenopathy, and existence of atypical lymphocytes. Serological tests for EB virus, cytomegalovirus and herpes simplex virus showed no significant change while the tests for HHV-6 showed increased titers of IgG antibody during the courses. We also examined HHV-6 DNA by real time quantitative PCR tests for HHV-6, and they appeared significantly high in the peripheral blood samples.

PMID: 12136654 [PubMed – indexed for MEDLINE]

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