Kansenshogaku Zasshi 2002 Jun;76(6):455-9
[Article in Japanese]
Tomita S, Takeda N, Isonuma H, Sato T, Ohshima H, Ebe T, Sekiya S, Matsumoto T, Hayashida Y, Watanabe K.
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Department of General Medicine, Juntendo University School of Medicine.
We experienced two cases of infectious mononucleosis-like syndrome associated with human herpesvirus 6 (HHV-6). One of the patients had been under medication for depression and the other one for schizophrenia. Both of them were taking carbamazepine for more than a week along with the other drugs.
The manifestation of the symptoms of those two were almost same, such as high fever, generalized eruption, liver dysfunction, lymph-adenopathy, and existence of atypical lymphocytes. Serological tests for EB virus, cytomegalovirus and herpes simplex virus showed no significant change while the tests for HHV-6 showed increased titers of IgG antibody during the courses. We also examined HHV-6 DNA by real time quantitative PCR tests for HHV-6, and they appeared significantly high in the peripheral blood samples.
PMID: 12136654 [PubMed – indexed for MEDLINE]