Acylcarnitine deficiency in Chronic Fatigue Syndrome (CFS)

One of the characteristic complaints of patients with chronic

fatigue syndrome (CFS) is the skeletal muscle-related symptom.

However, the abnormalities in the skeletal muscle that explain

the symptom are not clear. Herein, we show that our patients

with CFS had a deficiency of serum acylcarnitine. As carnitine

has an important role in energy production and modulation of

the intramitochondrial coenzyme A (CoA)/acyl-CoA ratio in the

skeletal muscle, this deficiency might induce an energy

deficit and/or abnormality of the intramitochondrial condition

in the skeletal muscle, thus resulting in general fatigue,

myalgia, muscle weakness, and postexertional malaise in

patients with CFS. Furthermore, the concentration of serum

acylcarnitine in patients with CFS tended to increase to the

normal level with the recovery of general fatigue. Therefore,

the measurement of acylcarnitine would be a useful tool for

the diagnosis and assessment of the degree of clinical

manifestation in patients with CFS.

Kuratsune H, Yamaguti K, Takahashi M, Misaki H, Tagawa S, Kitani T

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)

Leave a Reply