Arthritic symptoms can be ameliorated by targeting synovial fibroblasts – responsible for progressive destruction of cartilage and bone – with a novel genetically engineered adenovirus (Ad.GS1) designed by Chen et al.*
[* See “Amelioration of experimental arthritis by a telomerase-dependent conditionally replicating adenovirus that targets synovial fibroblasts,” by SY Chen, et al., Arthritis & Rhematism, Nov 2009. Note: Adenoviruses infect the linings of the respiratory tract, eyes, intestines & urinary tract, most often in early childhood. They’re a frequent cause of conjunctivitis (‘pink eye’), diarrhea and respiratory infections. Synovial fibroblasts are key players in RA joint destruction and are believed to play a role in spread of active RA from the first joints affected to other joints.]
Source: Nature Reviews Rheumatology, Jan 2010; 6(3). DOI:10.1038/nrrheum.2009.243, by Higgs R, Royal College of Surgeons in Ireland.