Adhesion molecules and cytokine expression in Fibromyalgia patients: Increased L-selectin on monocytes and neutrophils

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Journal: Journal of Neuroimmunology. 2007 Jun 27; [E-publication ahead of print]

Authors and affiliations: Macedo JA, Hesse J, Turner JD, Ammerlaan W, Gierens A, Hellhammer DH, Muller CP. Institute of Immunology, Laboratoire National de Santé, Luxembourg; Department of Immunology of the Graduate School of Psychobiology, University of Trier, Trier, Germany.

PMID: 17602758

Several lines of evidence implicate the immune system in the pathophysiology of Fibromyalgia (FM). We investigated the role of cytokines and adhesion molecules involved in immune cell trafficking and the influence of 1.5 mg of dexamethasone (DEX) per os on their expression. [Dexamethasone is an anti-inflammatory. Per os means taken by mouth.]

L-selectin was elevated on monocytes and neutrophils of FM patients. Differences in group response to DEX were observed for CD11b on NK cells, sICAM-1 and IL-2. [L-selectin is a cell adhesion molecule found on white blood cells (leukocytes) said to act as a "homing receptor" for them to enter tissues at the site of inflammation. Monocytes and neutrophils are two types of white blood cells.]

This study shows a slight disturbance in the innate immune system of FM patients, and suggests an enhanced adhesion and recruitment of leukocytes to inflammatory sites.