Advances in fibromyalgia (FM): possible role for central neurochemicals

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The neurophysiologic term allodynia has been applied to

fibromyalgia because people with that disorder experience pain

from pressure stimuli which are not normally painful. The

nociceptive neurotransmitters of animal studies are now

relevant to this human model of chronic, widespread pain.

Evidence is presented to implicate several chemical pain

mediators (including serotonin, substance P, nerve growth

factor, and dynorphin A) in the pathogenesis of fibromyalgia.

This perception is hopeful because it offers many new options

for the development of innovative therapy.

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