Amyloid beta-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer’s disease.

Given the increasing evidence of oxidative stress in AD brain and studies from different perspectives that appear to show a converging, central role for A beta in the pathogenesis and etiology of AD, insight into A beta-associated free radical oxidative stress will likely lead to a greater understanding of AD and, potentially, to better therapeutic strategies in this disorder.

This article outlined methods to investigate markers of oxidative stress induced by A beta in brain membrane systems. Especially important are markers for protein oxidation, lipid peroxidation, and ROS generation by A beta.

Oxidative stress and its sequelae are likely related to both necrotic and apoptotic mechanisms of neurotoxicity, and A beta-associated free radical oxidative stress may be of fundamental importance in Alzheimer’s disease etiology and pathogenesis. The methods described here provide some means for investigating this possibility.

Source: Methods Enzymol 1999;309:746-68

PMID: 10507060, UI: 99436948

(Department of Chemistry, University of Kentucky, Lexington 40506-0055, USA.)

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