An open clinical trial of venlafaxine treatment of fibromyalgia (FM)

Of 15 patients with fibromyalgia who were first evaluated for the
presence of Axis I psychiatric diagnoses by use of the
Structured Clinical Interview for DSM-IV, 11 completed an open
8-week trial with the novel antidepressant venlafaxine. Six
(55%) of 11 completers experienced a > or = 50% reduction of
fibromyalgia symptoms. The presence of lifetime psychiatric
disorders, particularly depressive and anxiety disorders,
predicted a positive response to venlafaxine. These findings
suggest that it is important to assess for comorbid
psychiatric disorders in patients with fibromyalgia and that
venlafaxine may be helpful to some of these patients.

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