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Administration of gammaglobulins to individuals without specific anti-Borrelia burgdorferi antibodies may lead to immunoglobulin G (IgG) conversion as detected by enzyme-linked immunosorbent assay (ELISA). In some cases however, complementary techniques such as Western blot or avidity will be of prime importance in distinguishing the start of an infection from the passive immunization induced by the gammaglobulins. In all cases, the key element before reaching conclusions in relation to any of these investigations remains the confrontation between the clinical context and the biological findings. This is the scenario that has been followed in our observation.