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Andrographis Useful for the Treatment of Inflammatory Diseases

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Editor’s Note: Andrographis and its main medicinal component, andrographolide, have been found to have powerful antimicrobial and anti-inflammatory effects in Lyme disease. Andrographis is discussed at length in Steven Harrod Buhner’s book, Healing Lyme.
 
Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis
 
Abstract
 
Andrographolide, a diterpenoid lactone obtained from plant Andrographis paniculata, is used in South Asian countries to relieve various inflammatory symptoms. To study the effects of this agent, the impact of andrographolide on production of inflammatory mediators were delineated in mouse peritoneal macrophages (PM?). Inflammatory mediators like nitric oxide (NO), tumor necrosis factor (TNF)-?, interleukin-6 and related molecular mechanisms of andrographolide-mediated inhibition of enzymes/transcription factors were studied.
 
In addition, the in vivo anti-inflammatory activity of andrographolide was evaluated in an adjuvant-induced arthritis rat model. The results indicated that andrographolide clearly inhibited the production of NO and TNF-? in lipopolysaccharide-activated PM? in a dose-related manner. Immunoblot analyses revealed that andrographolide suppressed activation of both inducible NO synthase and cyclo-oxygenase-2 by directly targeting nuclear transcription factor (NF)-?B.
 
Complete Freund’s Adjuvant-induced paw edema in rats was also significantly inhibited by andrographolide treatment. From the data, we concluded that andrographolide imparted anti-inflammatory effects by suppressing two key inflammatory enzymes and a signaling pathway that mediates expression of variety of inflammatory cytokines/agents in situ. It is plausible that eventually, after further toxicologic characterization, andrographolide might be useful as a drug for the clinical treatment of various inflammatory diseases like rheumatoid arthritis or diseases associated with joint pain.
 
Source: By Gupta S1, Mishra KP2, Singh SB1, Ganju L1. Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis.
Inflammopharmacology. 2017 Jul 22. doi: 10.1007/s10787-017-0375-7. [Epub ahead of print]
 

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