[Note: anti-cardiolipin antibodies are “anti-mitochondrial” antibodies that attack certain molecules that are common constituents of cell membranes and tend to increase clot formation – e.g., in veins and arteries. They are associated with many disorders, including immune disturbances such as lupus and Behcet’s disease, syphilis, recurrent miscarriage, and more. To read the full text of this paper, reporting on research co-sponsored by the National CFIDS Foundation, click here.]
Examination of anticardiolipin antibodies (ACAs) in the sera of patients clinically diagnosed with chronic fatigue syndrome (CFS) using an enzyme-linked immunoassay procedure demonstrated the presence of immunoglobulin M isotypes in 95% of CFS serum samples tested.
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The presence of immunoglobulin G and immunoglobulin A isotypes were also detected in a subset of the samples.
Future studies will focus on elucidating whether alterations to mitochondrial inner membranes and/or metabolic functions play a possible role in the expression of ACAs.
Source: Journal of Clinical Laboratory Analysis, Jul 21, 2009;23(4):210-212. PMID: 19623655, by Hokama Y, Campora CE, Hara C, Kuribayashi T, Le Huynh D, Yabusaki K. Department of Pathology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii.